Serum haptoglobin in Chinese patients with Alzheimer’s disease and mild cognitive impairment: A case-control study

•A case-control study from a population survey regarding serum Haptoglobin (Hp).•Serum Hp level increased from healthy controls through MCI cases to AD patients.•Serum Hp may correlate with the severity of AD. Serum level of Haptoglobin (Hp) maybe associated with Alzheimer’s disease (AD) and mild co...

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Bibliographic Details
Published in:Brain research bulletin 2018-03, Vol.137, p.301-305
Main Authors: Zhu, Cen-Jing, Jiang, Guo-Xin, Chen, Jin-Mei, Zhou, Zhi-Ming, Cheng, Qi
Format: Article
Language:English
Subjects:
Alzheimer’s disease
Haptoglobin
Inflammation
Medicin och hälsovetenskap
Mild cognitive impairment
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Summary:•A case-control study from a population survey regarding serum Haptoglobin (Hp).•Serum Hp level increased from healthy controls through MCI cases to AD patients.•Serum Hp may correlate with the severity of AD. Serum level of Haptoglobin (Hp) maybe associated with Alzheimer’s disease (AD) and mild cognitive impairment (MCI). To investigate associations between serum Hp and AD, as well as between Hp and MCI. Serum levels of Hp were measured and analyzed for 51 patients with AD, 139 patients with MCI and their healthy controls matched with sex and age. All study subjects were from a survey among residents aged 60 years and over in a community located in the southwest suburb of Shanghai. Serum levels of Hp were observed significantly higher in AD and MCI cases than controls (both p 
ISSN:0361-9230
1873-2747
1873-2747
DOI:10.1016/j.brainresbull.2018.01.005