Associations between self-rated health, sickness behaviour and inflammatory markers in primary care patients with allergic asthma: a longitudinal study

Allergic asthma is a chronic inflammatory disorder associated with elevated levels of immunoglobulin E (IgE), serum eosinophilic cationic protein (S-ECP), plasma eosinophil-derived neurotoxin (P-EDN) and fraction of exhaled nitric oxide (F E NO). Poor self-rated health and sickness behaviour has rep...

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Bibliographic Details
Published in:NPJ primary care respiratory medicine 2017-12, Vol.27 (1), p.67-6, Article 67
Main Authors: Lodin, Karin, Lekander, Mats, Syk, Jörgen, Alving, Kjell, Andreasson, Anna
Format: Article
Language:English
Subjects:
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692/308/174
Adult
Asthma
Asthma - physiopathology
Biomarkers - blood
Eosinophil Cationic Protein - blood
Eosinophil-Derived Neurotoxin - blood
Epidemiology
Exhalation
Female
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Health Status
Humans
Hälsovetenskap
Illness Behavior
Immunoglobulin E - blood
Immunology
Internal Medicine
Klinisk medicin
Longitudinal Studies
Lungmedicin och allergi
Male
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Middle Aged
Nitric Oxide - analysis
Pneumology/Respiratory System
Primary care
Primary Care Medicine
Self Report
Thoracic Surgery
Young Adult
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Summary:Allergic asthma is a chronic inflammatory disorder associated with elevated levels of immunoglobulin E (IgE), serum eosinophilic cationic protein (S-ECP), plasma eosinophil-derived neurotoxin (P-EDN) and fraction of exhaled nitric oxide (F E NO). Poor self-rated health and sickness behaviour has repeatedly been associated with inflammatory markers, but the nature of this relationship in chronic inflammatory disease is not known. Likewise, such findings largely rely on cross-sectional investigations. Self-rated health (How would you rate your general state of health?), sickness behaviour (mean rating of satisfaction with energy, sleep, fitness, appetite and memory), IgE, S-ECP, P-EDN, and F E NO were assessed in 181 non-smoking primary care patients with asthma in a 1-year longitudinal study. Associations between repeated measurements were calculated using mixed regression models and Spearman’s correlations for change scores. Poor self-rated health was associated with high levels of seasonal IgE ( p  = 0.05) and food IgE ( p  = 0.04), but not total IgE or inflammatory markers. An increase over 1 year in perennial IgE was associated with a worsening of self-rated health ( ρ  = 0.16, p  = 0.04). Poor self-rated health was associated with more pronounced sickness behaviour ( p  
ISSN:2055-1010
2055-1010
DOI:10.1038/s41533-017-0068-0