Immunologic burden links periodontitis to acute coronary syndrome

Periodontitis, a common polymicrobial inflammatory disease in the tooth supporting tissues, is a risk factor for coronary artery disease. One of the proposed underlying mechanisms is the systemic immune response to periodontal infection. We studied how serum antibodies against seven periodontal path...

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Bibliographic Details
Published in:Atherosclerosis 2018-01, Vol.268, p.177-184
Main Authors: Liljestrand, John M., Paju, Susanna, Pietiäinen, Milla, Buhlin, Kåre, Persson, G. Rutger, Nieminen, Markku S., Sinisalo, Juha, Mäntylä, Päivi, Pussinen, Pirkko J.
Format: Article
Language:English
Subjects:
Acute coronary syndrome
Acute Coronary Syndrome - blood
Acute Coronary Syndrome - diagnostic imaging
Acute Coronary Syndrome - immunology
Acute Coronary Syndrome - microbiology
Aged
Antibodies
Antibodies, Bacterial - blood
Bacteria
Bacteria - immunology
Bacterial Load
Bacteriological Techniques
Biomarkers - blood
Cardiovascular diseases
Coronary Angiography
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - immunology
Coronary Artery Disease - microbiology
Coronary Stenosis - blood
Coronary Stenosis - diagnostic imaging
Coronary Stenosis - immunology
Coronary Stenosis - microbiology
Cross-Sectional Studies
Enzyme-linked immunosorbent assay
Female
Finland
Host-Pathogen Interactions
Humans
Immunoglobulin A - blood
Immunoglobulin G - blood
Male
Medicin och hälsovetenskap
Middle Aged
Molecular mimicry
Periodontitis
Periodontitis - blood
Periodontitis - diagnosis
Periodontitis - immunology
Periodontitis - microbiology
Risk Factors
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Summary:Periodontitis, a common polymicrobial inflammatory disease in the tooth supporting tissues, is a risk factor for coronary artery disease. One of the proposed underlying mechanisms is the systemic immune response to periodontal infection. We studied how serum antibodies against seven periodontal pathogens and their subgingival levels associate with each other, periodontitis, and coronary artery disease. The Parogene cohort included 505 Finnish patients (mean age 63 y) who underwent coronary angiography, and clinical and radiographic oral examinations. Coronary diagnosis was defined as no significant coronary artery disease (
ISSN:0021-9150
1879-1484
1879-1484
DOI:10.1016/j.atherosclerosis.2017.12.007