Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population

Hypercholesterolemia promotes the inflammation against lipoproteins in atherosclerosis. Development of atherosclerosis is affected by the balance between pro-inflammatory effector T cells and anti-inflammatory regulatory T (Treg) cells. However, phenotype and function of T cell subpopulations in hyp...

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Bibliographic Details
Published in:Scientific reports 2017-11, Vol.7 (1), p.15655-10, Article 15655
Main Authors: Mailer, Reiner K. W., Gisterå, Anton, Polyzos, Konstantinos A., Ketelhuth, Daniel F. J., Hansson, Göran K.
Format: Article
Language:English
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Arteriosclerosis
Atherosclerosis
CD4 antigen
Cell culture
Cell lineage
Cell proliferation
Cholesterol
Dietary supplements
Effector cells
Foxp3 protein
Humanities and Social Sciences
Hypercholesterolemia
Inflammation
Lipoproteins
Lymphocytes
Lymphocytes T
Medicin och hälsovetenskap
multidisciplinary
Population number
Science
Science (multidisciplinary)
Splenocytes
Subpopulations
T cell receptors
Thymocytes
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Summary:Hypercholesterolemia promotes the inflammation against lipoproteins in atherosclerosis. Development of atherosclerosis is affected by the balance between pro-inflammatory effector T cells and anti-inflammatory regulatory T (Treg) cells. However, phenotype and function of T cell subpopulations in hypercholesterolemia remain to be investigated. Here, we found that cholesterol-containing diet increased the expression of the Treg cell lineage-defining transcription factor FoxP3 among thymocytes and splenocytes. Hypercholesterolemia elevated the FoxP3 expression level and population size of peripheral Treg cells, but did not prevent enhanced proliferation of stimulated T cells. Moreover, cholesterol supplementation in diet as well as in cell culture medium promoted T cell antigen receptor (TCR) signaling in CD4+ T cells. Our results demonstrate that hypercholesterolemia enhances TCR stimulation, Treg cell development as well as T cell proliferation. Thus, our findings may help to understand why hypercholesterolemia correlates with altered CD4+ T cell responses.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-15546-8