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The Contemporary Use of Radium-223 in Metastatic Castration-resistant Prostate Cancer

Radium-223 dichloride (radium-223) was approved for the treatment of patients with castration-resistant prostate cancer (CRPC) and symptomatic bone metastases in the United States and Europe in 2013. This followed a reported overall survival benefit for patients treated with radium-223 and best stan...

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Published in:Clinical genitourinary cancer 2018-02, Vol.16 (1), p.e223-e231
Main Authors: Heinrich, Daniel, Bektic, Jasmin, Bergman, Andries M., Caffo, Orazio, Cathomas, Richard, Chi, Kim N., Daugaard, Gedske, Keizman, Daniel, Kindblom, Jon, Kramer, Gero, Olmos, David, Omlin, Aurelius, Sridhar, Srikala S., Tucci, Marcello, van Oort, Inge, Nilsson, Sten
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cited_by cdi_FETCH-LOGICAL-c554t-f8efcddfb71e7da6cf75c20fcda63560caf34ebfc8cde3e8ff0829e1c585243b3
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container_title Clinical genitourinary cancer
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creator Heinrich, Daniel
Bektic, Jasmin
Bergman, Andries M.
Caffo, Orazio
Cathomas, Richard
Chi, Kim N.
Daugaard, Gedske
Keizman, Daniel
Kindblom, Jon
Kramer, Gero
Olmos, David
Omlin, Aurelius
Sridhar, Srikala S.
Tucci, Marcello
van Oort, Inge
Nilsson, Sten
description Radium-223 dichloride (radium-223) was approved for the treatment of patients with castration-resistant prostate cancer (CRPC) and symptomatic bone metastases in the United States and Europe in 2013. This followed a reported overall survival benefit for patients treated with radium-223 and best standard of care (BSoC) when compared with placebo and BSoC in the ALpharadin in SYMptomatic Prostate CAncer (ALSYMPCA) trial. At that time, docetaxel was the standard first-line choice for patients with metastatic CRPC (mCRPC). Since then, the treatment landscape has changed dramatically with new hormonal agents (abiraterone and enzalutamide) considered to be the first-line choice for many patients. The optimal patient profile for radium-223 in the modern setting, and its best use either in sequence or in combination with other approved agents are unclear, with few definitive guidelines available. This article reports on the views of a group of urologists and medical oncologists experienced in treating patients with mCRPC with radium-223 in routine clinical practice. The aim is to provide an overview of the current use of radium-223 in the treatment of patients with mCRPC, and to discuss best practices for patient selection and on-treatment monitoring. Where agreement was reached, guidance on the optimal use of radium-223 is provided.
doi_str_mv 10.1016/j.clgc.2017.08.020
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source ScienceDirect Journals
subjects Bone metastases
Medicin och hälsovetenskap
Patient selection
Targeted alpha therapy
Treatment monitoring
Treatment sequence
title The Contemporary Use of Radium-223 in Metastatic Castration-resistant Prostate Cancer
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