Chronic kidney disease is associated with poorer in-hospital outcomes in patients hospitalized with infections: Electronic record analysis from China

Predominantly based on studies from high-income countries, reduced estimated glomerular filtration rate (eGFR) has been associated with increased risk of infections and infection-related hospitalizations (IRHs). We here explore in-hospital outcomes of IRHs in patients with different kidney function....

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Bibliographic Details
Published in:Scientific reports 2017-09, Vol.7 (1), p.11530-10, Article 11530
Main Authors: Su, Guobin, Xu, Hong, Marrone, Gaetano, Lindholm, Bengt, Wen, Zehuai, Liu, Xusheng, Carrero, Juan-Jesus, Lundborg, Cecilia Stålsby
Format: Article
Language:English
Subjects:
692/4022/1585/104
692/699/255/1318
Aged
Aged, 80 and over
China
Critical Care - statistics & numerical data
Electronic Health Records - statistics & numerical data
Epidermal growth factor receptors
Facilities and Services Utilization
Female
Glomerular filtration rate
Health Care Costs - statistics & numerical data
Health risks
Hospitals
Humanities and Social Sciences
Humans
Infections
Infections - complications
Kidney diseases
Kidney transplantation
Kidneys
Length of Stay
Male
Middle Aged
multidisciplinary
Renal Insufficiency, Chronic - mortality
Renal Insufficiency, Chronic - pathology
Science
Science (multidisciplinary)
Survival Analysis
Treatment Outcome
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Summary:Predominantly based on studies from high-income countries, reduced estimated glomerular filtration rate (eGFR) has been associated with increased risk of infections and infection-related hospitalizations (IRHs). We here explore in-hospital outcomes of IRHs in patients with different kidney function. A total of 6,283 adults, not on renal replacement therapy, with a discharge diagnosis of infection, and with an eGFR 1–12 months before index hospitalization, were included from four hospitals in China. We compared in-hospital outcomes (death, intensive care unit (ICU) admission, length of hospital stay (LOHS) and medical expenses), between patients with and without chronic kidney disease (CKD, defined as eGFR ≤ 60 ml/min per 1.73 m 2 of body surface area) by mixed-effects logistic regression model or generalized linear model. The odds for in-hospital mortality (adjusted odds ratios (OR) = 1.41; 95% CI 1.02–1.96) and ICU admission (OR = 2.18; 95% CI 1.64–2.91) were higher among patients with CKD. The median LOHS was significantly higher for CKD patients (11 days vs. 10 days in non-CKD, P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-11861-2