Cerebrospinal fluid monoamine metabolite profiles in bipolar disorder, ADHD, and controls

Alterations in monoaminergic signaling are suggested as key aspects of the pathophysiology in bipolar disorder and ADHD, but it is not known if the monoamine metabolic profile differs between these disorders. One method to study monoaminergic systems in humans is to measure monoamine end-point metab...

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Bibliographic Details
Published in:JOURNAL OF NEURAL TRANSMISSION 2017-09, Vol.124 (9), p.1135-1143
Main Authors: Pålsson, Erik, Sellgren, Carl, Rydén, Eleonore, Kizza, Ruth, Pelanis, Aurimantas, Zetterberg, Henrik, Blennow, Kaj, Landén, Mikael
Format: Article
Language:English
Subjects:
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Neurology
Neurosciences
Psychiatry
Psychiatry and Preclinical Psychiatric Studies - Original
Psychiatry and Preclinical Psychiatric Studies - Original Article
Psykiatri
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Summary:Alterations in monoaminergic signaling are suggested as key aspects of the pathophysiology in bipolar disorder and ADHD, but it is not known if the monoamine metabolic profile differs between these disorders. One method to study monoaminergic systems in humans is to measure monoamine end-point metabolite concentrations in cerebrospinal fluid (CSF). Here, we analyzed CSF monoamine metabolite concentrations in 103 adults with bipolar disorder, 72 adults with ADHD, and 113 controls. Individuals with bipolar disorder had significantly higher homovanillic acid (HVA, 264 ± 112 nmol/L, p  
ISSN:0300-9564
1435-1463
1435-1463
DOI:10.1007/s00702-017-1746-3