Saliva and plasma levels of cardiac‐related biomarkers in post‐myocardial infarction patients

Aim To relate cardiac biomarkers, such as cystatin C and growth differentiation factor‐15 (GDF‐15) in saliva to myocardial infarction (MI) and to periodontal status, and to investigate the relation between salivary and plasma cardiac biomarkers. Materials and Methods Two hundred patients with MI adm...

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Published in:Journal of clinical periodontology 2017-07, Vol.44 (7), p.692-699
Main Authors: Rathnayake, Nilminie, Buhlin, Kåre, Kjellström, Barbro, Klinge, Bjorn, Löwbeer, Christian, Norhammar, Anna, Rydén, Lars, Sorsa, Timo, Tervahartiala, Taina, Gustafsson, Anders, Faire, Ulf, hl, Bertil, Nygren, Åke, Näsman, Per, Svenungsson, Elisabet
Format: Article
Language:English
Subjects:
acute myocardial infarction
Age
Biomarkers
Biomarkers - metabolism
Case-Control Studies
Cystatin C
Cystatin C - metabolism
Dentistry
Enzyme-Linked Immunosorbent Assay
Female
Fibrinogen
Growth Differentiation Factor 15 - metabolism
growth differentiation factor-15
Heart
Heart attacks
Heart diseases
Humans
Male
Middle Aged
Myocardial infarction
Myocardial Infarction - metabolism
periodontal disease
Periodontics
plasma
Plasma levels
Saliva
Saliva - chemistry
Studies
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Summary:Aim To relate cardiac biomarkers, such as cystatin C and growth differentiation factor‐15 (GDF‐15) in saliva to myocardial infarction (MI) and to periodontal status, and to investigate the relation between salivary and plasma cardiac biomarkers. Materials and Methods Two hundred patients with MI admitted to coronary care units and 200 matched controls without MI were included. Dental examination and collection of blood and saliva samples was performed 6–10 weeks after the MI for patients and in close proximity thereafter for controls. Analysing methods: ARCHITECT i4000SR, Immulite 2000 XPi or ELISA. Results The mean age was 62 ± 8 years and 84% were male. Total probing pocket depth, fibrinogen, white blood cell counts and HbA1c were higher in patients than controls. GDF‐15 levels correlated with most of the included clinical variables in both study groups. No correlation was found between plasma and saliva levels of cystatin C or GDF‐15. Conclusion Salivary cystatin C and GDF‐15 could not differentiate between MI patients and controls.
ISSN:0303-6979
1600-051X
1600-051X
DOI:10.1111/jcpe.12740