Saliva and plasma levels of cardiac‐related biomarkers in post‐myocardial infarction patients

Aim To relate cardiac biomarkers, such as cystatin C and growth differentiation factor‐15 (GDF‐15) in saliva to myocardial infarction (MI) and to periodontal status, and to investigate the relation between salivary and plasma cardiac biomarkers. Materials and Methods Two hundred patients with MI adm...

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Published in:Journal of clinical periodontology 2017-07, Vol.44 (7), p.692-699
Main Authors: Rathnayake, Nilminie, Buhlin, Kåre, Kjellström, Barbro, Klinge, Bjorn, Löwbeer, Christian, Norhammar, Anna, Rydén, Lars, Sorsa, Timo, Tervahartiala, Taina, Gustafsson, Anders, Faire, Ulf, hl, Bertil, Nygren, Åke, Näsman, Per, Svenungsson, Elisabet
Format: Article
Language:English
Subjects:
acute myocardial infarction
Age
Biomarkers
Biomarkers - metabolism
Case-Control Studies
Cystatin C
Cystatin C - metabolism
Dentistry
Enzyme-Linked Immunosorbent Assay
Female
Fibrinogen
Growth Differentiation Factor 15 - metabolism
growth differentiation factor-15
Heart
Heart attacks
Heart diseases
Humans
Male
Middle Aged
Myocardial infarction
Myocardial Infarction - metabolism
periodontal disease
Periodontics
plasma
Plasma levels
Saliva
Saliva - chemistry
Studies
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cited_by cdi_FETCH-LOGICAL-c4700-c2fdd8af5b5d14d509a0288fcd3804a1a4502a97ef450ddc45594f3e6708393e3
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container_title Journal of clinical periodontology
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creator Rathnayake, Nilminie
Buhlin, Kåre
Kjellström, Barbro
Klinge, Bjorn
Löwbeer, Christian
Norhammar, Anna
Rydén, Lars
Sorsa, Timo
Tervahartiala, Taina
Gustafsson, Anders
Faire, Ulf
hl, Bertil
Nygren, Åke
Näsman, Per
Svenungsson, Elisabet
description Aim To relate cardiac biomarkers, such as cystatin C and growth differentiation factor‐15 (GDF‐15) in saliva to myocardial infarction (MI) and to periodontal status, and to investigate the relation between salivary and plasma cardiac biomarkers. Materials and Methods Two hundred patients with MI admitted to coronary care units and 200 matched controls without MI were included. Dental examination and collection of blood and saliva samples was performed 6–10 weeks after the MI for patients and in close proximity thereafter for controls. Analysing methods: ARCHITECT i4000SR, Immulite 2000 XPi or ELISA. Results The mean age was 62 ± 8 years and 84% were male. Total probing pocket depth, fibrinogen, white blood cell counts and HbA1c were higher in patients than controls. GDF‐15 levels correlated with most of the included clinical variables in both study groups. No correlation was found between plasma and saliva levels of cystatin C or GDF‐15. Conclusion Salivary cystatin C and GDF‐15 could not differentiate between MI patients and controls.
doi_str_mv 10.1111/jcpe.12740
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Materials and Methods Two hundred patients with MI admitted to coronary care units and 200 matched controls without MI were included. Dental examination and collection of blood and saliva samples was performed 6–10 weeks after the MI for patients and in close proximity thereafter for controls. Analysing methods: ARCHITECT i4000SR, Immulite 2000 XPi or ELISA. Results The mean age was 62 ± 8 years and 84% were male. Total probing pocket depth, fibrinogen, white blood cell counts and HbA1c were higher in patients than controls. GDF‐15 levels correlated with most of the included clinical variables in both study groups. No correlation was found between plasma and saliva levels of cystatin C or GDF‐15. Conclusion Salivary cystatin C and GDF‐15 could not differentiate between MI patients and controls.</description><identifier>ISSN: 0303-6979</identifier><identifier>ISSN: 1600-051X</identifier><identifier>EISSN: 1600-051X</identifier><identifier>DOI: 10.1111/jcpe.12740</identifier><identifier>PMID: 28453865</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>acute myocardial infarction ; Age ; Biomarkers ; Biomarkers - metabolism ; Case-Control Studies ; Cystatin C ; Cystatin C - metabolism ; Dentistry ; Enzyme-Linked Immunosorbent Assay ; Female ; Fibrinogen ; Growth Differentiation Factor 15 - metabolism ; growth differentiation factor-15 ; Heart ; Heart attacks ; Heart diseases ; Humans ; Male ; Middle Aged ; Myocardial infarction ; Myocardial Infarction - metabolism ; periodontal disease ; Periodontics ; plasma ; Plasma levels ; Saliva ; Saliva - chemistry ; Studies</subject><ispartof>Journal of clinical periodontology, 2017-07, Vol.44 (7), p.692-699</ispartof><rights>2017 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd</rights><rights>2017 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons Ltd.</rights><rights>Copyright © 2017 John Wiley &amp; Sons A/S. 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Materials and Methods Two hundred patients with MI admitted to coronary care units and 200 matched controls without MI were included. Dental examination and collection of blood and saliva samples was performed 6–10 weeks after the MI for patients and in close proximity thereafter for controls. Analysing methods: ARCHITECT i4000SR, Immulite 2000 XPi or ELISA. Results The mean age was 62 ± 8 years and 84% were male. Total probing pocket depth, fibrinogen, white blood cell counts and HbA1c were higher in patients than controls. GDF‐15 levels correlated with most of the included clinical variables in both study groups. No correlation was found between plasma and saliva levels of cystatin C or GDF‐15. 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source Wiley-Blackwell Read & Publish Collection
subjects acute myocardial infarction
Age
Biomarkers
Biomarkers - metabolism
Case-Control Studies
Cystatin C
Cystatin C - metabolism
Dentistry
Enzyme-Linked Immunosorbent Assay
Female
Fibrinogen
Growth Differentiation Factor 15 - metabolism
growth differentiation factor-15
Heart
Heart attacks
Heart diseases
Humans
Male
Middle Aged
Myocardial infarction
Myocardial Infarction - metabolism
periodontal disease
Periodontics
plasma
Plasma levels
Saliva
Saliva - chemistry
Studies
title Saliva and plasma levels of cardiac‐related biomarkers in post‐myocardial infarction patients
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