Assessment of Protein Turnover in Health and Disease

To identify protein requirements, it is necessary to be familiar with basic physiology, practical methods, and dose response of protein delivery. This review evaluates available methodology, with emphasis on the limitations of existing techniques most often related to the underlying assumption. Hist...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition in Clinical Practice 2017-04, Vol.32 (1_suppl), p.15S-20S
Main Authors: Wernerman, Jan, Morris, Claudia R., Paddon-Jones, Douglas, Sarav, Menaka
Format: Article
Language:English
Subjects:
Aged
Aging
amino acids
critical illness
Dietary Proteins - metabolism
Humans
Medicin och hälsovetenskap
Middle Aged
nitrogen balance
Nursing
Nutrition Assessment
Nutritional Requirements
Oxidation-Reduction
protein
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To identify protein requirements, it is necessary to be familiar with basic physiology, practical methods, and dose response of protein delivery. This review evaluates available methodology, with emphasis on the limitations of existing techniques most often related to the underlying assumption. Historically, nitrogen balance has been the dominating technique. It is still the gold standard, although there are considerable problems related to the underlying assumptions to have reliable readings. When minimal requirements needed to be defined, the indicator amino acid oxidation technique came into practice. In situations of longer term steady states, it serves a purpose. In situations of disease or in aging, it has proven to be more problematic. More recently, whole-body protein turnover measurements have shown to be useful in situations where the underlying assumptions for the other techniques are not possible to meet.
ISSN:0884-5336
1941-2452
1941-2452
DOI:10.1177/0884533617694611