Parent of Origin and Prognosis in Familial Breast Cancer in Sweden

It has been suggested that prognosis in familial breast cancer could be influenced by the parent of origin, with a worse prognosis when inherited paternally. This study aimed to investigate the effect of the parent of origin on prognosis. Index patients were divided into two study groups depending o...

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Bibliographic Details
Published in:Anticancer research 2017-03, Vol.37 (3), p.1257-1262
Main Authors: Wendt, Camilla, Lindblom, Annika, Arver, Brita, VON Wachenfeldt, Anna, Margolin, Sara
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Breast Neoplasms - diagnosis
Breast Neoplasms - ethnology
Breast Neoplasms - mortality
Cohort Studies
Disease-Free Survival
Family Health
Fathers
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Mothers
Prognosis
Proportional Hazards Models
Risk
Sweden
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Summary:It has been suggested that prognosis in familial breast cancer could be influenced by the parent of origin, with a worse prognosis when inherited paternally. This study aimed to investigate the effect of the parent of origin on prognosis. Index patients were divided into two study groups depending on the parent of origin. Tumour characteristics and survival data for index patients were collected. In total, 319 families fulfilled the inclusion criteria. No significant difference in overall or recurrence-free survival between those with maternal and those with paternal inheritance was observed, with hazard ratios (HR) of 0.99 (95% confidence interval (CI)=0.54 to 1.80, p=0.97) and 1.22 (95% CI=0.78 to 1.92, p=0.38), respectively. We found no evidence for a worse prognosis in patients with paternally inherited breast cancer. However, only large differences in prognosis were excluded and the tendency for worse recurrence-free survival in the group with paternal inheritance therefore merits further study.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.11442