Endothelial maintenance in health and disease: Importance of sex differences

[Display omitted] The vascular endothelium has emerged as more than just an inert monolayer of cells lining the vascular bed. It represents the interface between the blood stream and vessel wall, and has a strategic role in regulating vascular homeostasis by the release of vasoactive substances. End...

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Bibliographic Details
Published in:Pharmacological research 2017-05, Vol.119, p.48-60
Main Authors: Mudrovcic, Neja, Arefin, Samsul, Van Craenenbroeck, Amaryllis H., Kublickiene, Karolina
Format: Article
Language:English
Subjects:
Animals
Cardiovascular
Cardiovascular Diseases - etiology
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - pathology
Endothelium
Endothelium, Vascular - metabolism
Endothelium, Vascular - pathology
Female
Homeostasis
Hormones
Humans
Male
Nitric oxide
Nitric Oxide - metabolism
Polycystic Ovary Syndrome - etiology
Polycystic Ovary Syndrome - metabolism
Polycystic Ovary Syndrome - pathology
Pre-Eclampsia - etiology
Pre-Eclampsia - metabolism
Pre-Eclampsia - pathology
Pregnancy
Renal Insufficiency, Chronic - etiology
Renal Insufficiency, Chronic - metabolism
Renal Insufficiency, Chronic - pathology
Sex
Sex Characteristics
Sex Factors
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Summary:[Display omitted] The vascular endothelium has emerged as more than just an inert monolayer of cells lining the vascular bed. It represents the interface between the blood stream and vessel wall, and has a strategic role in regulating vascular homeostasis by the release of vasoactive substances. Endothelial dysfunction contributes to the development and progression of cardiovascular disease. Recognition of sex-specific factors implicated in endothelial cell biology is important for the identification of clinically relevant preventive and/or therapeutic strategies. This review aims to give an overview of the recent advances in understanding the importance of sex specific observations in endothelial maintenance, both in healthy and diseased conditions. The female endothelium is highlighted in the context of polycystic ovary syndrome and pre-eclampsia. Furthermore, sex differences are explored in chronic kidney disease, which is currently appreciated as one of public health priorities. Overall, this review endorses integration of sex analysis in experimental and patient-oriented research in the exciting field of vascular biology.
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2017.01.011