Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: A nested case‐control study

• Published in: International journal of cancer 2017-04, Vol.140 (8), p.1727-1735
• Main Authors: Huang, Jiaqi, Zagai, Ulrika, Hallmans, Göran, Nyrén, Olof, Engstrand, Lars, Stolzenberg‐Solomon, Rachael, Duell, Eric J, Overvad, Kim, Katzke, Verena A, Kaaks, Rudolf, Jenab, Mazda, Park, Jin Young, Murillo, Raul, Trichopoulou, Antonia, Lagiou, Pagona, Bamia, Christina, Bradbury, Kathryn E, Riboli, Elio, Aune, Dagfinn, Tsilidis, Konstantinos K, Capellá, Gabriel, Agudo, Antonio, Krogh, Vittorio, Palli, Domenico, Panico, Salvatore, Weiderpass, Elisabete, Tjønneland, Anne, Olsen, Anja, Martínez, Begoña, Redondo‐Sanchez, Daniel, Chirlaque, Maria‐Dolores, HM Peeters, Petra, Regnér, Sara, Lindkvist, Björn, Naccarati, Alessio, Ardanaz, Eva, Larrañaga, Nerea, Boutron‐Ruault, Marie‐Christine, Rebours, Vinciane, Barré, Amélie, Bueno‐de‐Mesquita, H. B(as), Ye, Weimin
• Format: Article
• Language: English
• Subjects: Adult; Aged; Antigens, Bacterial - genetics; Antigens, Bacterial - isolation & purification; Bacterial Proteins - genetics; Bacterial Proteins - isolation & purification; Cancer; Cancer and Oncology; Cancer och onkologi; Case studies; Case-Control Studies; chronic corpus atrophic gastritis; Chronic diseases; Chronic infection; Clinical Medicine; Càncer de pàncrees; EPIC cohort; Estudi de casos; Europa; Europe; Female; Gastritis; Gastritis, Atrophic - epidemiology; Gastritis, Atrophic - genetics; Gastritis, Atrophic - microbiology; H. pylori infection; Health risk assessment; Health risks; Helicobacter Infections - epidemiology; Helicobacter Infections - genetics; Helicobacter Infections - microbiology; Helicobacter pylori; Helicobacter pylori - isolation & purification; Helicobacter pylori - pathogenicity; Helicobacteri pilòric; Humans; Infections; Klinisk medicin; Malalties cròniques; Male; Medical and Health Sciences; Medical research; Medicin och hälsovetenskap; Middle Aged; nested case-control study; Nutritional Status; Pancreas cancer; Pancreatic cancer; pancreatic cancer risk; Pancreatic Neoplasms - epidemiology; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - microbiology; Regression analysis
• ISSN: 0020-7136; 1097-0215; 1097-0215
• DOI: 10.1002/ijc.30590

The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case‐control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjusted for matching factors and other potential confounders. Our results showed that pancreatic cancer risk was neither associated with H. pylori seropositivity (OR = 0.96; 95% CI: 0.70, 1.31) nor CagA seropositivity (OR = 1.07; 95% CI: 0.77, 1.48). We also did not find any excess risk among individuals seropositive for H. pylori but seronegative for CagA, compared with the group seronegative for both antibodies (OR = 0.94; 95% CI: 0.63, 1.38). However, we found that chronic corpus atrophic gastritis was non‐significantly associated with an increased pancreatic cancer risk (OR = 1.35; 95% CI: 0.77, 2.37), and although based on small numbers, the excess risk was particularly marked among individuals seronegative for both H. pylori and CagA (OR = 5.66; 95% CI: 1.59, 20.19, p value for interaction