Proteolytic Mediators in Gestational Diabetes Mellitus and Gingivitis

• Published in: Journal of periodontology (1970) 2017-03, Vol.88 (3), p.289-297
• Main Authors: Akcalı, Aliye, Gümüş, Pınar, Özçaka, Özgün, Öztürk‐Ceyhan, Banu, Tervahartiala, Taina, Husu, Heidi, Heikkinen, Anna Maria, Sorsa, Timo, Buduneli, Nurcan
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers - blood; Biomarkers - metabolism; Dentistry; Diabetes, gestational; Diabetes, Gestational - enzymology; Enzyme-Linked Immunosorbent Assay; Female; gingival crevicular fluid; Gingival Crevicular Fluid - chemistry; gingivitis; Gingivitis - enzymology; Humans; Matrix Metalloproteinase 8 - blood; Matrix Metalloproteinase 8 - metabolism; Matrix Metalloproteinase 9 - blood; Matrix Metalloproteinase 9 - metabolism; matrix metalloproteinases; Medicin och hälsovetenskap; Pregnancy; saliva; Saliva - chemistry; serum; Tissue Inhibitor of Metalloproteinase-1 - blood; Tissue Inhibitor of Metalloproteinase-1 - metabolism
• ISSN: 0022-3492; 1943-3670; 1943-3670
• DOI: 10.1902/jop.2016.160158

Background: This study evaluates levels of matrix metalloproteinase (MMP)‐8, MMP‐9, and tissue inhibitor of MP‐1 (TIMP‐1) in biofluids of women with gestational diabetes mellitus (GDM) and systemically healthy counterparts with different statuses of periodontal health. Methods: Seventy‐one women with GDM and gingivitis (Gg), 30 women with GDM and healthy periodontium (Gh), 28 systemically and periodontally healthy women (Hh), and 37 systemically healthy women with gingivitis (Hg) were evaluated. MMP‐8, MMP‐9, and TIMP‐1 levels were determined in gingival crevicular fluid (GCF), saliva, and serum by immunofluorometric and enzyme‐linked immunosorbent assays. Full‐mouth clinical periodontal parameters were recorded. Results: GCF and serum MMP‐8 concentrations, serum MMP‐9 concentrations, and serum MMP‐8/MMP‐1 and MMP‐9/MMP‐1 molar ratios were significantly higher in Gg compared with Hg group (P