Maternal vitamin D deficiency and fetal distress/birth asphyxia: a population-based nested case-control study

Vitamin D deficiency causes not only skeletal problems but also muscle weakness, including heart muscle. If the fetal heart is also affected, it might be more susceptible to fetal distress and birth asphyxia. In this pilot study, we hypothesised that low maternal vitamin D levels are over-represente...

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Bibliographic Details
Published in:BMJ open 2016-01, Vol.6 (9), p.e009733-e009733
Main Authors: Lindqvist, Pelle G, Silva, Aldo T, Gustafsson, Sven A, Gidlöf, Sebastian
Format: Article
Language:English
Subjects:
Apgar score
Birth weight
Body mass index
Cesarean section
Gestational age
Heart rate
Medicin och hälsovetenskap
Muscle strength
Nutrition
Obstetrics and Gynaecology
Population
Population-based studies
Pregnancy
Regression analysis
Suffocation
Umbilical cord
Vagina
Vitamin D
Vitamin deficiency
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Summary:Vitamin D deficiency causes not only skeletal problems but also muscle weakness, including heart muscle. If the fetal heart is also affected, it might be more susceptible to fetal distress and birth asphyxia. In this pilot study, we hypothesised that low maternal vitamin D levels are over-represented in pregnancies with fetal distress/birth asphyxia. A population-based nested case-control study. Banked sera of 2496 women from the 12th week of pregnancy. Vitamin D levels were analysed using a direct competitive chemiluminescence immunoassay. Vitamin D levels in early gestation in women delivered by emergency caesarean section due to suspected fetal distress were compared to those in controls. Birth asphyxia was defined as Apgar
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2015-009733