Tudor staphylococcal nuclease: biochemistry and functions

Tudor staphylococcal nuclease (TSN, also known as Tudor-SN, SND1 or p100) is an evolutionarily conserved protein with invariant domain composition, represented by tandem repeat of staphylococcal nuclease domains and a tudor domain. Conservation along significant evolutionary distance, from protozoa...

Full description

Saved in:
Bibliographic Details
Published in:Cell death and differentiation 2016-11, Vol.23 (11), p.1739-1748
Main Authors: Gutierrez-Beltran, Emilio, Denisenko, Tatiana V, Zhivotovsky, Boris, Bozhkov, Peter V
Format: Article
Language:English
Subjects:
631/337
631/45
631/45/500
Animals
Apoptosis
Biochemistry
Biochemistry and Molecular Biology
Biokemi och molekylärbiologi
Biomedical and Life Sciences
Carcinogenesis - pathology
Cell Biology
Cell Cycle Analysis
Cell Death
Cellbiologi
Developmental Biology
Humans
Life Sciences
Medicin och hälsovetenskap
Micrococcal Nuclease - chemistry
Micrococcal Nuclease - metabolism
Models, Biological
Review
RNA Splicing - genetics
Stem Cells
Transcription, Genetic
Utvecklingsbiologi
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tudor staphylococcal nuclease (TSN, also known as Tudor-SN, SND1 or p100) is an evolutionarily conserved protein with invariant domain composition, represented by tandem repeat of staphylococcal nuclease domains and a tudor domain. Conservation along significant evolutionary distance, from protozoa to plants and animals, suggests important physiological functions for TSN. It is known that TSN is critically involved in virtually all pathways of gene expression, ranging from transcription to RNA silencing. Owing to its high protein–protein binding affinity coexistent with enzymatic activity, TSN can exert its biochemical function by acting as both a scaffolding molecule of large multiprotein complexes and/or as a nuclease. TSN is indispensible for normal development and stress resistance, whereas its increased expression is closely associated with various types of cancer. Thus, TSN is an attractive target for anti-cancer therapy and a potent tumor marker. Considering ever increasing interest to further understand a multitude of TSN-mediated processes and a mechanistic role of TSN in these processes, here we took an attempt to summarize and update the available information about this intriguing multifunctional protein.
ISSN:1350-9047
1476-5403
1476-5403
DOI:10.1038/cdd.2016.93