Preparation and clinical evaluation of Finastride gel in the treatment of idiopathic Hirsutism

Abstract Objective: Hirsutism is the presence of excess terminal hairs in females in a male-like pattern. The most accepted hypothesis for the development of hirsutism is increased 5α-reductase activity in hair follicles of hirsute women. Finasteride partially blocks the conversion of testosterone t...

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Bibliographic Details
Published in:Journal of drug assessment (London, U.K.) U.K.), 2015-01, Vol.4 (1), p.12-18
Main Authors: Tahvilian, Reza, Ebrahimi, Ali, Beiki, Omid, Nemati, Hoshang, Masoud, Sahar
Format: Article
Language:English
Subjects:
Finastride
Idiopathic hirsutism
Medicin och hälsovetenskap
Original
Testosterone
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Summary:Abstract Objective: Hirsutism is the presence of excess terminal hairs in females in a male-like pattern. The most accepted hypothesis for the development of hirsutism is increased 5α-reductase activity in hair follicles of hirsute women. Finasteride partially blocks the conversion of testosterone to dihydrotestosterone through inhibition of 5α-reductase in hair follicles. This study was designed to determine the efficacy of finasteride gel 0.25% in management of idiopathic hirsutism and treatment of hirsutism with topical finasteride to lessen the side-effects. Methods: Women after puberty that have idiopathic hirsutism criteria are divided randomly in two groups; treatment and control. The number of patients in each group is 15 and received finasteride and placebo gel once a day on their skins. The patients were visited every month by a dermatologist and the amount of response to the treatment and the patient satisfaction was recorded. Ferriman-Gallwey score of the treated area was determined. Results: After 6-months, mean thickness hairs in treating group were decreased from 102.00 ± 9.58 µm to 86.4 ± 11.4 µm (p 
ISSN:2155-6660
2155-6660
DOI:10.3109/21556660.2015.1056525