Local Diameter, Wall Stress, and Thrombus Thickness Influence the Local Growth of Abdominal Aortic Aneurysms

Purpose: To investigate the influence of the local diameter, the intraluminal thrombus (ILT) thickness, and wall stress on the local growth rate of abdominal aortic aneurysms. Methods: The infrarenal aortas of 90 asymptomatic abdominal aortic aneurysm (AAA) patients (mean age 70 years; 77 men) were...

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Bibliographic Details
Published in:Journal of endovascular therapy 2016-12, Vol.23 (6), p.957-966
Main Authors: Martufi, Giampaolo, Lindquist Liljeqvist, Moritz, Sakalihasan, Natzi, Panuccio, Giuseppe, Hultgren, Rebecka, Roy, Joy, Gasser, T. Christian
Format: Article
Language:English
Subjects:
abdominal aortic aneurysm
Aged
aneurysm diameter
aneurysm growth
Aorta, Abdominal
Aortic Aneurysm, Abdominal - pathology
Aortic Rupture
Computed Tomography Angiography
Disease Progression
Female
finite element analysis
Humans
intraluminal thrombus
Male
mechanical stress
Medicin och hälsovetenskap
Thrombosis - pathology
Treatment Outcome
wall stress
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Summary:Purpose: To investigate the influence of the local diameter, the intraluminal thrombus (ILT) thickness, and wall stress on the local growth rate of abdominal aortic aneurysms. Methods: The infrarenal aortas of 90 asymptomatic abdominal aortic aneurysm (AAA) patients (mean age 70 years; 77 men) were retrospectively reconstructed from at least 2 computed tomography angiography scans (median follow-up of 1 year) and biomechanically analyzed with the finite element method. Each individual AAA model was automatically sliced orthogonally to the lumen centerline and represented by 100 cross sections with corresponding diameters, ILT thicknesses, and wall stresses. The data were grouped according to these parameters for comparison of differences among the variables. Results: Diameter growth was continuously distributed over the entire aneurysm sac, reaching absolute and relative median peaks of 3.06 mm/y and 7.3%/y, respectively. The local growth rate was dependent on the local baseline diameter, the local ILT thickness, and for wall segments not covered by ILT, also on the local wall stress level (all p
ISSN:1526-6028
1545-1550
1545-1550
DOI:10.1177/1526602816657086