Cellular energetics as a target for tumor cell elimination

Investigation of cancer cell metabolism has revealed variability of the metabolic profiles among different types of tumors. According to the most classical model of cancer bioenergetics, malignant cells primarily use glycolysis as the major metabolic pathway and produce large quantities of lactate w...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2016-02, Vol.81 (2), p.65-79
Main Authors: Maximchik, P. V., Kulikov, A. V., Zhivotovsky, B. D., Gogvadze, V. G.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Biochemistry
Bioenergetics
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Biosynthesis
Cancer
Cancer cells
Cell interaction
Cell Line, Tumor
Energy Metabolism - drug effects
Health aspects
Humans
Life Sciences
Medicin och hälsovetenskap
Microbiology
Mitochondria
Mitochondria - drug effects
Mitochondria - metabolism
Neoplasms - drug therapy
Neoplasms - metabolism
Observations
Review
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Summary:Investigation of cancer cell metabolism has revealed variability of the metabolic profiles among different types of tumors. According to the most classical model of cancer bioenergetics, malignant cells primarily use glycolysis as the major metabolic pathway and produce large quantities of lactate with suppressed oxidative phosphorylation even in the presence of ample oxygen. This is referred to as aerobic glycolysis, or the Warburg effect. However, a growing number of recent studies provide evidence that not all cancer cells depend on glycolysis, and, moreover, oxidative phosphorylation is essential for tumorigenesis. Thus, it is necessary to consider distinctive patterns of cancer metabolism in each specific case. Chemoresistance of cancer cells is associated with decreased sensitivity to different types of antitumor agents. Stimulation of apoptosis is a major strategy for elimination of cancer cells, and therefore activation of mitochondrial functions with direct impact on mitochondria to destabilize them appears to be an important approach to the induction of cell death. Consequently, the design of combination therapies using acclaimed cytotoxic agents directed to induction of apoptosis and metabolic agents affecting cancer cell bioenergetics are prospective strategies for antineoplastic therapy.
ISSN:0006-2979
1608-3040
1608-3040
DOI:10.1134/S0006297916020012