Low-grade inflammation is a major contributor of impaired attentional set shifting in obese subjects

Highlights • Sixty-six obese subject and twenty normal-weight subjects were included. • Obese subjects with higher levels of CRP (> 5 mg/L) exhibited impaired cognitive flexibility. • The group of obese subjects with lower CRP levels was similar to the control group. • The role of CRP in altered...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2016-11, Vol.58, p.63-68
Main Authors: Lasselin, Julie, Magne, Eric, Beau, Cédric, Aubert, Agnès, Dexpert, Sandra, Carrez, Julie, Layé, Sophie, Forestier, Damien, Ledaguenel, Patrick, Capuron, Lucile
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Animal genetics
Attention - physiology
Attentional set shifting
C-reactive protein
C-Reactive Protein - metabolism
Cognition
Cognitive flexibility
Executive Function - physiology
Female
Genetics
Humans
Inflammation
Life Sciences
Low-grade inflammation
Male
Medicin och hälsovetenskap
Obesity
Obesity - physiopathology
Obesity - psychology
Psychiatry
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Summary:Highlights • Sixty-six obese subject and twenty normal-weight subjects were included. • Obese subjects with higher levels of CRP (> 5 mg/L) exhibited impaired cognitive flexibility. • The group of obese subjects with lower CRP levels was similar to the control group. • The role of CRP in altered cognitive flexibility in obesity was confirmed by regression analyses. • Inflammation represents a major contributor of cognitive flexibility alterations in obesity.
ISSN:0889-1591
1090-2139
1090-2139
DOI:10.1016/j.bbi.2016.05.013