The Hippo signal transduction network for exercise physiologists

The ubiquitous transcriptional coactivators Yap (gene symbol Yap1) and Taz (gene symbol Wwtr1) regulate gene expression mainly by coactivating the Tead transcription factors. Being at the center of the Hippo signaling network, Yap and Taz are regulated by the Hippo kinase cassette and additionally b...

Full description

Saved in:
Bibliographic Details
Published in:Journal of applied physiology (1985) 2016-05, Vol.120 (10), p.1105-1117
Main Authors: Gabriel, Brendan M, Hamilton, D Lee, Tremblay, Annie M, Wackerhage, Henning
Format: Article
Language:English
Subjects:
ACE inhibitors
Animals
Cardiomyocytes
Exercise - physiology
Glucose
Homeostasis
Humans
Muscle, Skeletal - metabolism
Muscle, Skeletal - physiology
Musculoskeletal system
Physical Conditioning, Animal - physiology
Protein Serine-Threonine Kinases - metabolism
Proteins
Signal Transduction - physiology
Synthesis Review
Transcription Factors - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The ubiquitous transcriptional coactivators Yap (gene symbol Yap1) and Taz (gene symbol Wwtr1) regulate gene expression mainly by coactivating the Tead transcription factors. Being at the center of the Hippo signaling network, Yap and Taz are regulated by the Hippo kinase cassette and additionally by a plethora of exercise-associated signals and signaling modules. These include mechanotransduction, the AKT-mTORC1 network, the SMAD transcription factors, hypoxia, glucose homeostasis, AMPK, adrenaline/epinephrine and angiotensin II through G protein-coupled receptors, and IL-6. Consequently, exercise should alter Hippo signaling in several organs to mediate at least some aspects of the organ-specific adaptations to exercise. Indeed, Tead1 overexpression in muscle fibers has been shown to promote a fast-to-slow fiber type switch, whereas Yap in muscle fibers and cardiomyocytes promotes skeletal muscle hypertrophy and cardiomyocyte adaptations, respectively. Finally, genome-wide association studies in humans have linked the Hippo pathway members LATS2, TEAD1, YAP1, VGLL2, VGLL3, and VGLL4 to body height, which is a key factor in sports.
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.01076.2015