Human Papillomavirus neutralizing and cross-reactive antibodies induced in HIV-positive subjects after vaccination with quadrivalent and bivalent HPV vaccines

Highlights • Immunogenicity has emerged as an important outcome measure for HPV vaccine research. • HIV-infected individuals received either Gardasil™ or Cervarix™ and Ab response was measured. • Two HPV serology methods produced similar results for HPV immunogenicity. • HPV vaccines were highly imm...

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Bibliographic Details
Published in:Vaccine 2016-03, Vol.34 (13), p.1559-1565
Main Authors: Faust, Helena, Toft, Lars, Sehr, Peter, Müller, Martin, Bonde, Jesper, Forslund, Ola, Østergaard, Lars, Tolstrup, Martin, Dillner, Joakim
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Antibody Formation
Cervarix
Cervical cancer
Clinical Medicine
Cross Reactions
Female
Females
Gardasil
HIV
HIV Seropositivity
HPV
Human immunodeficiency virus
Human papillomavirus
Human papillomavirus 16
Human papillomavirus 18
Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 - immunology
Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 - therapeutic use
Humans
Immunization
Immunization Schedule
Infectious Medicine
Infektionsmedicin
Klinisk medicin
Lentivirus
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Middle Aged
Neutralization Tests
Papillomaviridae
Papillomavirus Infections - prevention & control
Papillomavirus Vaccines - immunology
Papillomavirus Vaccines - therapeutic use
Pseudovirions
Retroviridae
Seroconversion
Vaccines
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Summary:Highlights • Immunogenicity has emerged as an important outcome measure for HPV vaccine research. • HIV-infected individuals received either Gardasil™ or Cervarix™ and Ab response was measured. • Two HPV serology methods produced similar results for HPV immunogenicity. • HPV vaccines were highly immunogenic in adult HIV-infected population. • The results support HPV vaccination of HIV-positive adults.
ISSN:0264-410X
1873-2518
1873-2518
DOI:10.1016/j.vaccine.2016.02.019