Long-chain saturated and monounsaturated fatty acids associate with development of premature infants up to 18 months of age

Abstract Myelination is important perinatally and highly dependent on long-chain saturated and monounsaturated fatty acids. Long-chain polyunsaturated fatty acids, nowadays often supplemented, inhibit oleic acid synthesis. Using data from a premature cohort, we studied if nervonic, lignoceric and ol...

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Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2016-04, Vol.107, p.43-49
Main Authors: Strandvik, Birgitta, Ntoumani, Eleni, Lundqvist-Persson, Cristina, Sabel, Karl-Göran
Format: Article
Language:English
Subjects:
Acetyltransferases - blood
Advanced Basic Science
Child Development
Clinical Medicine
Desaturase
Elongase
Endocrinology & Metabolism
Fatty Acid Desaturases - blood
Fatty Acids, Monounsaturated - blood
Female
Humans
Infant
Infant, Newborn
Infant, Premature - blood
Infant, Premature - growth & development
Klinisk medicin
LCPUFA
Lignoceric acid
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Nervonic acid
Oleic acid
Pediatrics
Pediatrik
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Summary:Abstract Myelination is important perinatally and highly dependent on long-chain saturated and monounsaturated fatty acids. Long-chain polyunsaturated fatty acids, nowadays often supplemented, inhibit oleic acid synthesis. Using data from a premature cohort, we studied if nervonic, lignoceric and oleic acids correlated to growth and early development up to 18 months corrected age. Small for gestational age infants had lower concentrations than infants appropriate for gestational age. Only oleic acid was negatively correlated to long-chain polyunsaturated fatty acids. Oleic and lignoceric acids correlated to social interaction at one month, and nervonic acid to mental, psychomotor and behavioral development at 6, 10 and 18 months, also when adjusted for several confounders. Negative association between oleic acid and long-chain polyunsaturated fatty acids suggests inhibition of delta-9 desaturase, and nervonic acid´s divergent correlation to lignoceric and oleic acids suggests different metabolism in neonatal period. Our results may have implications for the supplementation of premature infants.
ISSN:0952-3278
1532-2823
1532-2823
DOI:10.1016/j.plefa.2016.01.002