Association of thalassemia major and gingival inflammation: A pilot study

Highlights • We hypothesized that thalassemia major may affect levels of MMPs biofluids and thereby deteriorate clinical periodontal status. • We examine changes in the level of MMPs in thalassemia major patients. • Thalassemia major may exacerbate the local inflammatory response. • Higher serum TIM...

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Bibliographic Details
Published in:Archives of oral biology 2016-04, Vol.64, p.80-84
Main Authors: Gümüş, Pınar, Kahraman-Çeneli, Selda, Akcali, Aliye, Sorsa, Timo, Tervahartiala, Taina, Buduneli, Nurcan, Özçaka, Özgün
Format: Article
Language:English
Subjects:
Adolescent
Adult
Advanced Basic Science
beta-Thalassemia - blood
beta-Thalassemia - enzymology
beta-Thalassemia - pathology
Cross-Sectional Studies
Dental Plaque Index
Dentistry
Female
Fluoroimmunoassay - methods
Gingiva
Gingival Crevicular Fluid - enzymology
Gingivitis - blood
Gingivitis - enzymology
Gingivitis - pathology
Humans
Inflammation
Male
Matrix metalloproteinase 8
Matrix Metalloproteinase 8 - analysis
Matrix Metalloproteinase 8 - blood
Matrix metalloproteinase 9
Matrix Metalloproteinase 9 - analysis
Matrix Metalloproteinase 9 - blood
Medicin och hälsovetenskap
Middle Aged
Periodontal Attachment Loss
Periodontal Index
Periodontal Pocket
Pilot Projects
Saliva - chemistry
Saliva - enzymology
Thalassemia major
Tissue inhibitor of metalloproteinase-1
Tissue Inhibitor of Metalloproteinase-1 - analysis
Tissue Inhibitor of Metalloproteinase-1 - blood
Young Adult
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Summary:Highlights • We hypothesized that thalassemia major may affect levels of MMPs biofluids and thereby deteriorate clinical periodontal status. • We examine changes in the level of MMPs in thalassemia major patients. • Thalassemia major may exacerbate the local inflammatory response. • Higher serum TIMP-1 levels in thalassemia major could be result of their systemic drug usage.
ISSN:0003-9969
1879-1506
1879-1506
DOI:10.1016/j.archoralbio.2015.12.008