Bowman–Birk inhibitor concentrate suppresses experimental autoimmune neuritis via shifting macrophages from M1 to M2 subtype

Highlights • Bowman–Birk inhibitor concentrate inhibited experimental autoimmune neuritis signs. • Suppression of experimental autoimmune neuritis related to T cells insufficiency. • The suppressed mechanism is associated with shifting macrophages from M1 to M2.

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Bibliographic Details
Published in:Immunology letters 2016-03, Vol.171, p.15-25
Main Authors: Jin, Tao, Yu, Hong, Wang, Dan, Zhang, Hongliang, Zhang, Bo, Quezada, Hernan Concha, Zhu, Jie, Zhu, Wei
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Anti-Inflammatory Agents - therapeutic use
Bowman–Birk inhibitor concentrate
CD4-Positive T-Lymphocytes - drug effects
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - drug effects
CD8-Positive T-Lymphocytes - immunology
Cell Differentiation - drug effects
Cells, Cultured
Cytokines - metabolism
Experimental autoimmune neuritis
Glycine max - immunology
Guillain-Barre Syndrome - drug therapy
Guillain-Barre Syndrome - immunology
Guillain–Barré syndrome
Humans
Lymphocyte Activation - drug effects
M1/M2 cells
Macrophage
Macrophages - drug effects
Macrophages - immunology
Male
Neuritis, Autoimmune, Experimental - drug therapy
Neuritis, Autoimmune, Experimental - immunology
Plant Proteins - therapeutic use
Rats
Rats, Inbred Lew
Th1-Th2 Balance - drug effects
Trypsin Inhibitor, Bowman-Birk Soybean - therapeutic use
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Description
Summary:Highlights • Bowman–Birk inhibitor concentrate inhibited experimental autoimmune neuritis signs. • Suppression of experimental autoimmune neuritis related to T cells insufficiency. • The suppressed mechanism is associated with shifting macrophages from M1 to M2.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2016.01.004