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Bowman–Birk inhibitor concentrate suppresses experimental autoimmune neuritis via shifting macrophages from M1 to M2 subtype

Highlights • Bowman–Birk inhibitor concentrate inhibited experimental autoimmune neuritis signs. • Suppression of experimental autoimmune neuritis related to T cells insufficiency. • The suppressed mechanism is associated with shifting macrophages from M1 to M2.

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Published in:	Immunology letters 2016-03, Vol.171, p.15-25
Main Authors:	Jin, Tao, Yu, Hong, Wang, Dan, Zhang, Hongliang, Zhang, Bo, Quezada, Hernan Concha, Zhu, Jie, Zhu, Wei
Format:	Article
Language:	English
Subjects:	Allergy and Immunology Animals Anti-Inflammatory Agents - therapeutic use Bowman–Birk inhibitor concentrate CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell Differentiation - drug effects Cells, Cultured Cytokines - metabolism Experimental autoimmune neuritis Glycine max - immunology Guillain-Barre Syndrome - drug therapy Guillain-Barre Syndrome - immunology Guillain–Barré syndrome Humans Lymphocyte Activation - drug effects M1/M2 cells Macrophage Macrophages - drug effects Macrophages - immunology Male Neuritis, Autoimmune, Experimental - drug therapy Neuritis, Autoimmune, Experimental - immunology Plant Proteins - therapeutic use Rats Rats, Inbred Lew Th1-Th2 Balance - drug effects Trypsin Inhibitor, Bowman-Birk Soybean - therapeutic use
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creator	Jin, Tao Yu, Hong Wang, Dan Zhang, Hongliang Zhang, Bo Quezada, Hernan Concha Zhu, Jie Zhu, Wei
description	Highlights • Bowman–Birk inhibitor concentrate inhibited experimental autoimmune neuritis signs. • Suppression of experimental autoimmune neuritis related to T cells insufficiency. • The suppressed mechanism is associated with shifting macrophages from M1 to M2.
doi_str_mv	10.1016/j.imlet.2016.01.004
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subjects	Allergy and Immunology Animals Anti-Inflammatory Agents - therapeutic use Bowman–Birk inhibitor concentrate CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell Differentiation - drug effects Cells, Cultured Cytokines - metabolism Experimental autoimmune neuritis Glycine max - immunology Guillain-Barre Syndrome - drug therapy Guillain-Barre Syndrome - immunology Guillain–Barré syndrome Humans Lymphocyte Activation - drug effects M1/M2 cells Macrophage Macrophages - drug effects Macrophages - immunology Male Neuritis, Autoimmune, Experimental - drug therapy Neuritis, Autoimmune, Experimental - immunology Plant Proteins - therapeutic use Rats Rats, Inbred Lew Th1-Th2 Balance - drug effects Trypsin Inhibitor, Bowman-Birk Soybean - therapeutic use
title	Bowman–Birk inhibitor concentrate suppresses experimental autoimmune neuritis via shifting macrophages from M1 to M2 subtype
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