Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes

Over 100 associated genetic loci have been robustly associated with schizophrenia. Gene prioritization and pathway analysis have focused on a priori hypotheses and thus may have been unduly influenced by prior assumptions and missed important causal genes and pathways. Using a data-driven approach,...

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Bibliographic Details
Published in:Human molecular genetics 2016-03, Vol.25 (6), p.1247-1254
Main Authors: Pers, Tune H, Timshel, Pascal, Ripke, Stephan, Lent, Samantha, Sullivan, Patrick F, O'Donovan, Michael C, Franke, Lude, Hirschhorn, Joel N
Format: Article
Language:English
Subjects:
Association Studies
Chromosome Mapping
Genetic Association Studies
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Ion Channels - genetics
Medicin och hälsovetenskap
Polymorphism, Single Nucleotide
Schizophrenia - genetics
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Summary:Over 100 associated genetic loci have been robustly associated with schizophrenia. Gene prioritization and pathway analysis have focused on a priori hypotheses and thus may have been unduly influenced by prior assumptions and missed important causal genes and pathways. Using a data-driven approach, we show that genes in associated loci: (1) are highly expressed in cortical brain areas; (2) are enriched for ion channel pathways (false discovery rates
ISSN:0964-6906
1460-2083
1460-2083
DOI:10.1093/hmg/ddw007