Ankle arthritis predicts polyarticular disease course and unfavourable outcome in children with juvenile idiopathic arthritis

To evaluate the occurrence, clinical characteristics and prognostic factors associated with ankle arthritis in children with juvenile idiopathic arthritis (JIA). 440 children with JIA were followed for eight years in a prospective Nordic population-based cohort study. Data on remission was available...

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Bibliographic Details
Published in:CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 2015, Vol.33 (5), p.751-757
Main Authors: Esbjörnsson, Anna-Clara, Aalto, Kristiina, Broström, Eva W, Fasth, Anders, Herlin, Troels, Nielsen, Susan, Nordal, Ellen, Peltoniemi, Suvi, Rygg, Marite, Zak, Marek, Berntson, Lillemor
Format: Article
Language:English
Subjects:
Age of Onset
ankle
Ankle Joint
Antirheumatic Agents - therapeutic use
arthritis
Arthritis, Juvenile - diagnosis
Arthritis, Juvenile - drug therapy
Arthritis, Juvenile - epidemiology
Child
Child, Preschool
Disease Progression
Female
Follow-Up Studies
foot
Humans
juvenile idiopathic arthritis
Logistic Models
Male
Multivariate Analysis
Odds Ratio
Osteoarthritis - diagnosis
Osteoarthritis - drug therapy
Osteoarthritis - epidemiology
Pediatrics
Pediatrik
Predictive Value of Tests
prognosis
Prospective Studies
Remission Induction
Retrospective Studies
Risk Factors
Scandinavian and Nordic Countries - epidemiology
Time Factors
Treatment Outcome
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Summary:To evaluate the occurrence, clinical characteristics and prognostic factors associated with ankle arthritis in children with juvenile idiopathic arthritis (JIA). 440 children with JIA were followed for eight years in a prospective Nordic population-based cohort study. Data on remission was available for 427 of these children. Occurrence of clinically assessed ankle arthritis was analysed in relation to JIA category, clinical characteristics and remission data eight years after disease onset. In 440 children with JIA, 251 (57%) experienced ankle arthritis during the first eight years of disease. Ankle arthritis was least common in the persistent oligoarticular category (25%) and most common in children with extended oligoarticular (83%) and polyarticular RF-negative (85%) JIA. Children who developed ankle arthritis during the first year of disease were younger at disease onset (median age 4.9 (IQR 2.1-8.8) vs. 6.6 (IQR 2.8-10.1) years, p
ISSN:0392-856X
1593-098X