Impaired Phenotype and Function of T Follicular Helper Cells in HIV-1-Infected Children Receiving ART

T follicular helper (Tfh) cells are important components in development of specific humoral immune responses; whether the number and biology of Tfh cells is impaired in HIV-1-infected children is not yet studied.The frequency, phenotype, and function of Tfh cells and B cells were determined in blood...

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Published in:Medicine (Baltimore) 2015-07, Vol.94 (27), p.e1125-e1125
Main Authors: Bekele, Yonas, Amu, Sylvie, Bobosha, Kidist, Lantto, Rebecka, Nilsson, Anna, Endale, Birtukan, Gebre, Meseret, Aseffa, Abraham, Rethi, Bence, Howe, Rawleigh, Chiodi, Francesca
Format: Article
Language:English
Subjects:
Anti-Retroviral Agents - therapeutic use
B-Lymphocytes - metabolism
Child
Child, Preschool
Cytokines - biosynthesis
Female
Flow Cytometry
HIV Infections - drug therapy
HIV Infections - immunology
HIV-1
Humans
Inducible T-Cell Co-Stimulator Protein - biosynthesis
Lymphocyte Activation
Male
Medicin och hälsovetenskap
Observational Study
Phenotype
Programmed Cell Death 1 Receptor - biosynthesis
T-Lymphocytes, Helper-Inducer - metabolism
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Summary:T follicular helper (Tfh) cells are important components in development of specific humoral immune responses; whether the number and biology of Tfh cells is impaired in HIV-1-infected children is not yet studied.The frequency, phenotype, and function of Tfh cells and B cells were determined in blood of HIV-1-infected children receiving antiretroviral therapy (ART) and age-matched controls. Flow cytometry was used to characterize the frequency of Tfh cells and B cell subsets. Cytokine expression was measured after in vitro activation of Tfh cells.A reduced frequency of memory Tfh cells (P 
ISSN:0025-7974
1536-5964
1536-5964
DOI:10.1097/MD.0000000000001125