Clinical use of insulin degludec

Highlights • Insulin degludec (IDeg) is a novel basal insulin with improved PK and PD properties. • IDeg improves glycaemic control and significantly reduces the risk of hypoglycaemia. • When switching to IDeg, this can be done unit-to-unit or may require dose reduction. • Dose adjustment with IDeg...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2015-07, Vol.109 (1), p.19-31
Main Authors: Vora, Jiten, Cariou, Bertrand, Evans, Marc, Gross, Jorge Luiz, Harris, Stewart, Landstedt-Hallin, Lena, Mithal, Ambrish, Rodriguez, Martín Rodríguez, Meneghini, Luigi
Format: Article
Language:English
Subjects:
Blood Glucose - drug effects
Clinical practice
Diabetes
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - drug therapy
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Dosing
Drug Administration Schedule
Endocrinology & Metabolism
Humans
Hypoglycaemia
Hypoglycemia - blood
Hypoglycemia - chemically induced
Insulin
Insulin - pharmacokinetics
Insulin - therapeutic use
Insulin degludec
Insulin Glargine - pharmacokinetics
Insulin Glargine - therapeutic use
Insulin, Long-Acting - adverse effects
Insulin, Long-Acting - pharmacokinetics
Insulin, Long-Acting - therapeutic use
Weight Gain - drug effects
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Summary:Highlights • Insulin degludec (IDeg) is a novel basal insulin with improved PK and PD properties. • IDeg improves glycaemic control and significantly reduces the risk of hypoglycaemia. • When switching to IDeg, this can be done unit-to-unit or may require dose reduction. • Dose adjustment with IDeg can be carried out once-weekly in steps of 2 units. • The ultra-long duration of action of IDeg allows for dose flexibility, if needed.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2015.04.002