Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders

Genome-wide association studies (GWAS) have been extensively used to study common complex diseases such as coronary artery disease (CAD), revealing 153 suggestive CAD loci, of which at least 46 have been validated as having genome-wide significance. However, these loci collectively explain 

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2015-03, Vol.65 (8), p.830-845
Main Authors: Björkegren, Johan L M, Kovacic, Jason C, Dudley, Joel T, Schadt, Eric E
Format: Article
Language:English
Subjects:
Coronary Artery Disease - genetics
Genetic Loci
Genetic Predisposition to Disease
Genetic Variation
Genome-Wide Association Study
Humans
Medicin och hälsovetenskap
Polymorphism, Single Nucleotide
Risk Factors
Online Access:Get full text
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Description
Summary:Genome-wide association studies (GWAS) have been extensively used to study common complex diseases such as coronary artery disease (CAD), revealing 153 suggestive CAD loci, of which at least 46 have been validated as having genome-wide significance. However, these loci collectively explain 
ISSN:0735-1097
1558-3597
1558-3597
DOI:10.1016/j.jacc.2014.12.033