Increasing Incidence of Chronic Graft-versus-Host Disease in Allogeneic Transplantation: A Report from the Center for International Blood and Marrow Transplant Research

• Published in: Biology of blood and marrow transplantation 2015-02, Vol.21 (2), p.266-274
• Main Authors: Arai, Sally, Arora, Mukta, Wang, Tao, Spellman, Stephen R, He, Wensheng, Couriel, Daniel R, Urbano-Ispizua, Alvaro, Cutler, Corey S, Bacigalupo, Andrea A, Battiwalla, Minoo, Flowers, Mary E, Juckett, Mark B, Lee, Stephanie J, Loren, Alison W, Klumpp, Thomas R, Prockup, Susan E, Ringdén, Olle T.H, Savani, Bipin N, Socié, Gérard, Schultz, Kirk R, Spitzer, Thomas, Teshima, Takanori, Bredeson, Christopher N, Jacobsohn, David A, Hayashi, Robert J, Drobyski, William R, Frangoul, Haydar A, Akpek, Görgün, Ho, Vincent T, Lewis, Victor A, Gale, Robert Peter, Koreth, John, Chao, Nelson J, Aljurf, Mahmoud D, Cooper, Brenda W, Laughlin, Mary J, Hsu, Jack W, Hematti, Peiman, Verdonck, Leo F, Solh, Melhelm M, Norkin, Maxim, Reddy, Vijay, Martino, Rodrigo, Gadalla, Shahinaz, Goldberg, Jenna D, McCarthy, Philip L, Pérez-Simón, José A, Khera, Nandita, Lewis, Ian D, Atsuta, Yoshiko, Olsson, Richard F, Saber, Wael, Waller, Edmund K, Blaise, Didier, Pidala, Joseph A, Martin, Paul J, Satwani, Prakash, Bornhäuser, Martin, Inamoto, Yoshihiro, Weisdorf, Daniel J, Horowitz, Mary M, Pavletic, Steven Z
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Allogeneic transplant; Bone Marrow Transplantation - adverse effects; cGVHD; Child; Child, Preschool; Chronic Disease; Female; Graft vs Host Disease - etiology; Graft vs Host Disease - mortality; Graft vs Host Disease - pathology; Hematology, Oncology and Palliative Medicine; Hematopoietic Stem Cell Transplantation - adverse effects; Humans; Incidence; Infant; Infant, Newborn; International Cooperation; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - mortality; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy; Leukemia, Myeloid, Acute - mortality; Leukemia, Myeloid, Acute - pathology; Leukemia, Myeloid, Acute - therapy; Male; Medicin och hälsovetenskap; Middle Aged; Myeloablative Agonists - therapeutic use; Myelodysplastic Syndromes - mortality; Myelodysplastic Syndromes - pathology; Myelodysplastic Syndromes - therapy; Nonrelapse mortality; Odds Ratio; Survival Analysis; Transplantation, Homologous
• ISSN: 1083-8791; 1523-6536; 1523-6536
• DOI: 10.1016/j.bbmt.2014.10.021

Abstract Although transplant practices have changed over the last decades, no information is available on trends in incidence and outcome of chronic graft-versus-host disease (cGVHD) over time. This study used the central database of the Center for International Blood and Marrow Transplant Research (CIBMTR) to describe time trends for cGVHD incidence, nonrelapse mortality, and risk factors for cGVHD. The 12-year period was divided into 3 intervals, 1995 to 1999, 2000 to 2003, and 2004 to 2007, and included 26,563 patients with acute leukemia, chronic myeloid leukemia, and myelodysplastic syndrome. Multivariate analysis showed an increased incidence of cGVHD in more recent years (odds ratio = 1.19, P