Loading…
Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis
Background: Alcohol is a risk factor for cancer of the oral cavity, pharynx, oesophagus, colorectum, liver, larynx and female breast, whereas its impact on other cancers remains controversial. Methods: We investigated the effect of alcohol on 23 cancer types through a meta-analytic approach. We used...
Saved in:
| Published in: | British journal of cancer 2015-02, Vol.112 (3), p.580-593 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c554t-89491af6276c86de6d89e2dae86f78048180aa5cfb50f7e802d87a8d5607255d3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c554t-89491af6276c86de6d89e2dae86f78048180aa5cfb50f7e802d87a8d5607255d3 |
| container_end_page | 593 |
| container_issue | 3 |
| container_start_page | 580 |
| container_title | British journal of cancer |
| container_volume | 112 |
| creator | Bagnardi, V Rota, M Botteri, E Tramacere, I Islami, F Fedirko, V Scotti, L Jenab, M Turati, F Pasquali, E Pelucchi, C Galeone, C Bellocco, R Negri, E Corrao, G Boffetta, P La Vecchia, C |
| description | Background:
Alcohol is a risk factor for cancer of the oral cavity, pharynx, oesophagus, colorectum, liver, larynx and female breast, whereas its impact on other cancers remains controversial.
Methods:
We investigated the effect of alcohol on 23 cancer types through a meta-analytic approach. We used dose–response meta-regression models and investigated potential sources of heterogeneity.
Results:
A total of 572 studies, including 486 538 cancer cases, were identified. Relative risks (RRs) for heavy drinkers compared with nondrinkers and occasional drinkers were 5.13 for oral and pharyngeal cancer, 4.95 for oesophageal squamous cell carcinoma, 1.44 for colorectal, 2.65 for laryngeal and 1.61 for breast cancer; for those neoplasms there was a clear dose–risk relationship. Heavy drinkers also had a significantly higher risk of cancer of the stomach (RR 1.21), liver (2.07), gallbladder (2.64), pancreas (1.19) and lung (1.15). There was indication of a positive association between alcohol consumption and risk of melanoma and prostate cancer. Alcohol consumption and risk of Hodgkin’s and Non-Hodgkin’s lymphomas were inversely associated.
Conclusions:
Alcohol increases risk of cancer of oral cavity and pharynx, oesophagus, colorectum, liver, larynx and female breast. There is accumulating evidence that alcohol drinking is associated with some other cancers such as pancreas and prostate cancer and melanoma. |
| doi_str_mv | 10.1038/bjc.2014.579 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_517479</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3578524511</sourcerecordid><originalsourceid>FETCH-LOGICAL-c554t-89491af6276c86de6d89e2dae86f78048180aa5cfb50f7e802d87a8d5607255d3</originalsourceid><addsrcrecordid>eNptkc1uEzEUhS1U1KalO9ZopG47wfaM_1ggVVULSJXYwNo49p3G6Yw92JNW3fUdeEOeBIeEKpVY2b7n87n36iD0luA5wY18v1jZOcWknTOhXqEZYQ2tiaTiAM0wxqLGiuIjdJzzqjwVluIQHVHWUqqwmqEfF72Ny9hXNoa8HsbJx1CZ4KrsJ6jzCNZ33lbWBAupSj7ffahMgYcxwRJC9vdQuZjh99OvBHksJlANMJnaBNM_Zp_foNed6TOc7s4T9P366tvl5_rm66cvlxc3tWWsnWqpWkVMx6ngVnIH3EkF1BmQvBMSt5JIbAyz3YLhToDE1ElhpGMcC8qYa05QvfXNDzCuF3pMfjDpUUfj9a50V26gGRGtUIX_uOWLMoCzEKZk-hffXirBL_VtvNdtyxrebAzOdgYp_lxDnvQqrlPZOmvCGVacMUULdb6lbIo5J-ieOxCsN_npkp_e5KfZ36ne7U_1DP8LbG_NIoVbSHtd_2f4B0dUqMk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1650965592</pqid></control><display><type>article</type><title>Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis</title><source>PubMed Central</source><creator>Bagnardi, V ; Rota, M ; Botteri, E ; Tramacere, I ; Islami, F ; Fedirko, V ; Scotti, L ; Jenab, M ; Turati, F ; Pasquali, E ; Pelucchi, C ; Galeone, C ; Bellocco, R ; Negri, E ; Corrao, G ; Boffetta, P ; La Vecchia, C</creator><creatorcontrib>Bagnardi, V ; Rota, M ; Botteri, E ; Tramacere, I ; Islami, F ; Fedirko, V ; Scotti, L ; Jenab, M ; Turati, F ; Pasquali, E ; Pelucchi, C ; Galeone, C ; Bellocco, R ; Negri, E ; Corrao, G ; Boffetta, P ; La Vecchia, C</creatorcontrib><description>Background:
Alcohol is a risk factor for cancer of the oral cavity, pharynx, oesophagus, colorectum, liver, larynx and female breast, whereas its impact on other cancers remains controversial.
Methods:
We investigated the effect of alcohol on 23 cancer types through a meta-analytic approach. We used dose–response meta-regression models and investigated potential sources of heterogeneity.
Results:
A total of 572 studies, including 486 538 cancer cases, were identified. Relative risks (RRs) for heavy drinkers compared with nondrinkers and occasional drinkers were 5.13 for oral and pharyngeal cancer, 4.95 for oesophageal squamous cell carcinoma, 1.44 for colorectal, 2.65 for laryngeal and 1.61 for breast cancer; for those neoplasms there was a clear dose–risk relationship. Heavy drinkers also had a significantly higher risk of cancer of the stomach (RR 1.21), liver (2.07), gallbladder (2.64), pancreas (1.19) and lung (1.15). There was indication of a positive association between alcohol consumption and risk of melanoma and prostate cancer. Alcohol consumption and risk of Hodgkin’s and Non-Hodgkin’s lymphomas were inversely associated.
Conclusions:
Alcohol increases risk of cancer of oral cavity and pharynx, oesophagus, colorectum, liver, larynx and female breast. There is accumulating evidence that alcohol drinking is associated with some other cancers such as pancreas and prostate cancer and melanoma.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2014.579</identifier><identifier>PMID: 25422909</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/699/67 ; Alcohol Drinking - adverse effects ; Alcohol Drinking - epidemiology ; Alcohol use ; Biomedical and Life Sciences ; Biomedicine ; Breast Neoplasms - epidemiology ; Cancer Research ; Carcinoma, Squamous Cell - epidemiology ; Case-Control Studies ; Dose-Response Relationship, Drug ; Drug Resistance ; Epidemiology ; Esophageal Neoplasms - epidemiology ; Esophageal Squamous Cell Carcinoma ; Female ; Humans ; Incidence ; Larynx ; Liver ; Male ; Medical research ; Melanoma ; Melanoma - epidemiology ; Meta-analysis ; Molecular Medicine ; Mouth Neoplasms - epidemiology ; Neoplasms - epidemiology ; Oncology ; Pancreas ; Pharyngeal Neoplasms - epidemiology ; Prostate cancer ; Prostatic Neoplasms - epidemiology ; Risk Factors ; Science ; Working groups</subject><ispartof>British journal of cancer, 2015-02, Vol.112 (3), p.580-593</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Feb 3, 2015</rights><rights>Copyright © 2015 Cancer Research UK 2015 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-89491af6276c86de6d89e2dae86f78048180aa5cfb50f7e802d87a8d5607255d3</citedby><cites>FETCH-LOGICAL-c554t-89491af6276c86de6d89e2dae86f78048180aa5cfb50f7e802d87a8d5607255d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453639/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453639/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25422909$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:130761757$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Bagnardi, V</creatorcontrib><creatorcontrib>Rota, M</creatorcontrib><creatorcontrib>Botteri, E</creatorcontrib><creatorcontrib>Tramacere, I</creatorcontrib><creatorcontrib>Islami, F</creatorcontrib><creatorcontrib>Fedirko, V</creatorcontrib><creatorcontrib>Scotti, L</creatorcontrib><creatorcontrib>Jenab, M</creatorcontrib><creatorcontrib>Turati, F</creatorcontrib><creatorcontrib>Pasquali, E</creatorcontrib><creatorcontrib>Pelucchi, C</creatorcontrib><creatorcontrib>Galeone, C</creatorcontrib><creatorcontrib>Bellocco, R</creatorcontrib><creatorcontrib>Negri, E</creatorcontrib><creatorcontrib>Corrao, G</creatorcontrib><creatorcontrib>Boffetta, P</creatorcontrib><creatorcontrib>La Vecchia, C</creatorcontrib><title>Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
Alcohol is a risk factor for cancer of the oral cavity, pharynx, oesophagus, colorectum, liver, larynx and female breast, whereas its impact on other cancers remains controversial.
Methods:
We investigated the effect of alcohol on 23 cancer types through a meta-analytic approach. We used dose–response meta-regression models and investigated potential sources of heterogeneity.
Results:
A total of 572 studies, including 486 538 cancer cases, were identified. Relative risks (RRs) for heavy drinkers compared with nondrinkers and occasional drinkers were 5.13 for oral and pharyngeal cancer, 4.95 for oesophageal squamous cell carcinoma, 1.44 for colorectal, 2.65 for laryngeal and 1.61 for breast cancer; for those neoplasms there was a clear dose–risk relationship. Heavy drinkers also had a significantly higher risk of cancer of the stomach (RR 1.21), liver (2.07), gallbladder (2.64), pancreas (1.19) and lung (1.15). There was indication of a positive association between alcohol consumption and risk of melanoma and prostate cancer. Alcohol consumption and risk of Hodgkin’s and Non-Hodgkin’s lymphomas were inversely associated.
Conclusions:
Alcohol increases risk of cancer of oral cavity and pharynx, oesophagus, colorectum, liver, larynx and female breast. There is accumulating evidence that alcohol drinking is associated with some other cancers such as pancreas and prostate cancer and melanoma.</description><subject>692/499</subject><subject>692/699/67</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohol Drinking - epidemiology</subject><subject>Alcohol use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Cancer Research</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Case-Control Studies</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Esophageal Neoplasms - epidemiology</subject><subject>Esophageal Squamous Cell Carcinoma</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Larynx</subject><subject>Liver</subject><subject>Male</subject><subject>Medical research</subject><subject>Melanoma</subject><subject>Melanoma - epidemiology</subject><subject>Meta-analysis</subject><subject>Molecular Medicine</subject><subject>Mouth Neoplasms - epidemiology</subject><subject>Neoplasms - epidemiology</subject><subject>Oncology</subject><subject>Pancreas</subject><subject>Pharyngeal Neoplasms - epidemiology</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Risk Factors</subject><subject>Science</subject><subject>Working groups</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNptkc1uEzEUhS1U1KalO9ZopG47wfaM_1ggVVULSJXYwNo49p3G6Yw92JNW3fUdeEOeBIeEKpVY2b7n87n36iD0luA5wY18v1jZOcWknTOhXqEZYQ2tiaTiAM0wxqLGiuIjdJzzqjwVluIQHVHWUqqwmqEfF72Ny9hXNoa8HsbJx1CZ4KrsJ6jzCNZ33lbWBAupSj7ffahMgYcxwRJC9vdQuZjh99OvBHksJlANMJnaBNM_Zp_foNed6TOc7s4T9P366tvl5_rm66cvlxc3tWWsnWqpWkVMx6ngVnIH3EkF1BmQvBMSt5JIbAyz3YLhToDE1ElhpGMcC8qYa05QvfXNDzCuF3pMfjDpUUfj9a50V26gGRGtUIX_uOWLMoCzEKZk-hffXirBL_VtvNdtyxrebAzOdgYp_lxDnvQqrlPZOmvCGVacMUULdb6lbIo5J-ieOxCsN_npkp_e5KfZ36ne7U_1DP8LbG_NIoVbSHtd_2f4B0dUqMk</recordid><startdate>20150203</startdate><enddate>20150203</enddate><creator>Bagnardi, V</creator><creator>Rota, M</creator><creator>Botteri, E</creator><creator>Tramacere, I</creator><creator>Islami, F</creator><creator>Fedirko, V</creator><creator>Scotti, L</creator><creator>Jenab, M</creator><creator>Turati, F</creator><creator>Pasquali, E</creator><creator>Pelucchi, C</creator><creator>Galeone, C</creator><creator>Bellocco, R</creator><creator>Negri, E</creator><creator>Corrao, G</creator><creator>Boffetta, P</creator><creator>La Vecchia, C</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20150203</creationdate><title>Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis</title><author>Bagnardi, V ; Rota, M ; Botteri, E ; Tramacere, I ; Islami, F ; Fedirko, V ; Scotti, L ; Jenab, M ; Turati, F ; Pasquali, E ; Pelucchi, C ; Galeone, C ; Bellocco, R ; Negri, E ; Corrao, G ; Boffetta, P ; La Vecchia, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-89491af6276c86de6d89e2dae86f78048180aa5cfb50f7e802d87a8d5607255d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>692/499</topic><topic>692/699/67</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Alcohol Drinking - epidemiology</topic><topic>Alcohol use</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Cancer Research</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Case-Control Studies</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Esophageal Neoplasms - epidemiology</topic><topic>Esophageal Squamous Cell Carcinoma</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Larynx</topic><topic>Liver</topic><topic>Male</topic><topic>Medical research</topic><topic>Melanoma</topic><topic>Melanoma - epidemiology</topic><topic>Meta-analysis</topic><topic>Molecular Medicine</topic><topic>Mouth Neoplasms - epidemiology</topic><topic>Neoplasms - epidemiology</topic><topic>Oncology</topic><topic>Pancreas</topic><topic>Pharyngeal Neoplasms - epidemiology</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - epidemiology</topic><topic>Risk Factors</topic><topic>Science</topic><topic>Working groups</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bagnardi, V</creatorcontrib><creatorcontrib>Rota, M</creatorcontrib><creatorcontrib>Botteri, E</creatorcontrib><creatorcontrib>Tramacere, I</creatorcontrib><creatorcontrib>Islami, F</creatorcontrib><creatorcontrib>Fedirko, V</creatorcontrib><creatorcontrib>Scotti, L</creatorcontrib><creatorcontrib>Jenab, M</creatorcontrib><creatorcontrib>Turati, F</creatorcontrib><creatorcontrib>Pasquali, E</creatorcontrib><creatorcontrib>Pelucchi, C</creatorcontrib><creatorcontrib>Galeone, C</creatorcontrib><creatorcontrib>Bellocco, R</creatorcontrib><creatorcontrib>Negri, E</creatorcontrib><creatorcontrib>Corrao, G</creatorcontrib><creatorcontrib>Boffetta, P</creatorcontrib><creatorcontrib>La Vecchia, C</creatorcontrib><collection>Springer Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bagnardi, V</au><au>Rota, M</au><au>Botteri, E</au><au>Tramacere, I</au><au>Islami, F</au><au>Fedirko, V</au><au>Scotti, L</au><au>Jenab, M</au><au>Turati, F</au><au>Pasquali, E</au><au>Pelucchi, C</au><au>Galeone, C</au><au>Bellocco, R</au><au>Negri, E</au><au>Corrao, G</au><au>Boffetta, P</au><au>La Vecchia, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2015-02-03</date><risdate>2015</risdate><volume>112</volume><issue>3</issue><spage>580</spage><epage>593</epage><pages>580-593</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
Alcohol is a risk factor for cancer of the oral cavity, pharynx, oesophagus, colorectum, liver, larynx and female breast, whereas its impact on other cancers remains controversial.
Methods:
We investigated the effect of alcohol on 23 cancer types through a meta-analytic approach. We used dose–response meta-regression models and investigated potential sources of heterogeneity.
Results:
A total of 572 studies, including 486 538 cancer cases, were identified. Relative risks (RRs) for heavy drinkers compared with nondrinkers and occasional drinkers were 5.13 for oral and pharyngeal cancer, 4.95 for oesophageal squamous cell carcinoma, 1.44 for colorectal, 2.65 for laryngeal and 1.61 for breast cancer; for those neoplasms there was a clear dose–risk relationship. Heavy drinkers also had a significantly higher risk of cancer of the stomach (RR 1.21), liver (2.07), gallbladder (2.64), pancreas (1.19) and lung (1.15). There was indication of a positive association between alcohol consumption and risk of melanoma and prostate cancer. Alcohol consumption and risk of Hodgkin’s and Non-Hodgkin’s lymphomas were inversely associated.
Conclusions:
Alcohol increases risk of cancer of oral cavity and pharynx, oesophagus, colorectum, liver, larynx and female breast. There is accumulating evidence that alcohol drinking is associated with some other cancers such as pancreas and prostate cancer and melanoma.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25422909</pmid><doi>10.1038/bjc.2014.579</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0920 |
| ispartof | British journal of cancer, 2015-02, Vol.112 (3), p.580-593 |
| issn | 0007-0920 1532-1827 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_517479 |
| source | PubMed Central |
| subjects | 692/499 692/699/67 Alcohol Drinking - adverse effects Alcohol Drinking - epidemiology Alcohol use Biomedical and Life Sciences Biomedicine Breast Neoplasms - epidemiology Cancer Research Carcinoma, Squamous Cell - epidemiology Case-Control Studies Dose-Response Relationship, Drug Drug Resistance Epidemiology Esophageal Neoplasms - epidemiology Esophageal Squamous Cell Carcinoma Female Humans Incidence Larynx Liver Male Medical research Melanoma Melanoma - epidemiology Meta-analysis Molecular Medicine Mouth Neoplasms - epidemiology Neoplasms - epidemiology Oncology Pancreas Pharyngeal Neoplasms - epidemiology Prostate cancer Prostatic Neoplasms - epidemiology Risk Factors Science Working groups |
| title | Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T20%3A06%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Alcohol%20consumption%20and%20site-specific%20cancer%20risk:%20a%20comprehensive%20dose%E2%80%93response%20meta-analysis&rft.jtitle=British%20journal%20of%20cancer&rft.au=Bagnardi,%20V&rft.date=2015-02-03&rft.volume=112&rft.issue=3&rft.spage=580&rft.epage=593&rft.pages=580-593&rft.issn=0007-0920&rft.eissn=1532-1827&rft.coden=BJCAAI&rft_id=info:doi/10.1038/bjc.2014.579&rft_dat=%3Cproquest_swepu%3E3578524511%3C/proquest_swepu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c554t-89491af6276c86de6d89e2dae86f78048180aa5cfb50f7e802d87a8d5607255d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1650965592&rft_id=info:pmid/25422909&rfr_iscdi=true |