P300 amplitude and response speed relate to preserved cognitive function in relapsing–remitting multiple sclerosis

Highlights • P300 amplitudes and response times in choice reaction tasks (visual and auditory stimulation) have strong association with cognitive function in relapsing–remitting MS which differs from the absent or weak association in healthy controls. • These associations were not an epiphenomenon o...

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Bibliographic Details
Published in:Clinical neurophysiology 2015-04, Vol.126 (4), p.689-697
Main Authors: Sundgren, Mathias, Nikulin, Vadim V, Maurex, Liselotte, Wahlin, Åke, Piehl, Fredrik, Brismar, Tom
Format: Article
Language:English
Subjects:
Acoustic Stimulation - methods
Adult
Cognition - physiology
Cognitive function
Cross-Sectional Studies
Event-related potential
Event-Related Potentials, P300 - physiology
Female
Humans
Male
Medicin och hälsovetenskap
Middle Aged
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - diagnosis
Multiple Sclerosis, Relapsing-Remitting - physiopathology
Neurology
P300
Photic Stimulation - methods
Reaction Time - physiology
Response time
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Summary:Highlights • P300 amplitudes and response times in choice reaction tasks (visual and auditory stimulation) have strong association with cognitive function in relapsing–remitting MS which differs from the absent or weak association in healthy controls. • These associations were not an epiphenomenon of the cognitive decline in patients, since parietal P300 amplitudes and response times were normal. • Patients had an increase in the visual P300 amplitude in the frontal region suggesting activation of compensatory networks.
ISSN:1388-2457
1872-8952
1872-8952
DOI:10.1016/j.clinph.2014.07.024