Posaconazole Concentrations in Human Tissues after Allogeneic Stem Cell Transplantation

Few data have been published regarding posaconazole tissue concentrations in humans. We analyzed tissue concentrations in biopsy specimens taken at autopsy from seven patients who received posaconazole prophylaxis because of graft-versus-host disease. The results were compared to plasma concentratio...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2014-08, Vol.58 (8), p.4941-4943
Main Authors: BLENNOW, Ola, ELIASSON, Erik, PETTERSSON, Tommy, POHANKA, Anton, SZAKOS, Attila, EL-SERAFI, Ibrahim, HASSAN, Moustapha, RINGDEN, Olle, MATTSSON, Jonas
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal Agents
Antifungal Agents - blood
Antifungal Agents - pharmacokinetics
Antifungal Agents - therapeutic use
Autopsy
Biological and medical sciences
Brain Chemistry
Clinical Therapeutics
Graft vs Host Disease
Graft vs Host Disease - etiology
Graft vs Host Disease - pathology
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cell Transplantation - adverse effects
Humans
Kidney - chemistry
Liver - chemistry
Lung - chemistry
Medical sciences
Medicin och hälsovetenskap
Mycoses - prevention & control
Myocardium - chemistry
Pharmacology. Drug treatments
Transplantation, Homologous
Triazoles
Triazoles - blood
Triazoles - pharmacokinetics
Triazoles - therapeutic use
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Summary:Few data have been published regarding posaconazole tissue concentrations in humans. We analyzed tissue concentrations in biopsy specimens taken at autopsy from seven patients who received posaconazole prophylaxis because of graft-versus-host disease. The results were compared to plasma concentrations collected before death. Tissue concentrations suggestive of an accumulation of posaconazole were found in the heart, lung, liver, and kidney but not in the brain.
ISSN:0066-4804
1098-6596
1098-6596
DOI:10.1128/AAC.03252-14