Serum and Salivary Matrix Metalloproteinases, Neutrophil Elastase, Myeloperoxidase in Patients with Chronic or Aggressive Periodontitis

Salivary, serum matrix metalloproteinase-8 (MMP-8), tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), neutrophil elastase (NE), and myeloperoxidase (MPO) levels were investigated in generalized chronic periodontitis (GCP), generalized aggressive periodontitis (GAgP), and healthy groups. Whol...

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Bibliographic Details
Published in:Inflammation 2014-10, Vol.37 (5), p.1771-1778
Main Authors: Nizam, Nejat, Gümüş, Pınar, Pitkänen, Jari, Tervahartiala, Taina, Sorsa, Timo, Buduneli, Nurcan
Format: Article
Language:English
Subjects:
Adult
Aggressive Periodontitis - blood
Aggressive Periodontitis - diagnosis
Aggressive Periodontitis - metabolism
Biomarkers - analysis
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Chronic Periodontitis - blood
Chronic Periodontitis - diagnosis
Chronic Periodontitis - metabolism
Female
Humans
Immunology
Internal Medicine
Leukocyte Elastase - analysis
Leukocyte Elastase - blood
Male
Matrix Metalloproteinases - analysis
Matrix Metalloproteinases - blood
Middle Aged
Pathology
Peroxidase - analysis
Peroxidase - blood
Pharmacology/Toxicology
Rheumatology
Saliva - metabolism
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Summary:Salivary, serum matrix metalloproteinase-8 (MMP-8), tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), neutrophil elastase (NE), and myeloperoxidase (MPO) levels were investigated in generalized chronic periodontitis (GCP), generalized aggressive periodontitis (GAgP), and healthy groups. Whole-mouth clinical periodontal measurements were recorded. Salivary, serum concentrations of MMP-8, MPO, TIMP-1, and NE were determined by immunofluorometric assay or ELISA in 18 patients with GCP, 23 patients with GAgP, 18 individuals with healthy periodontium. Patients in the GAgP group were younger than the other groups ( p  
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-014-9907-0