Exposure to Maternal Smoking During Pregnancy as a Risk Factor for Tobacco Use in Adult Offspring

Nicotine from maternal smoking during pregnancy can cross the placental barrier, possibly resulting in fetal brain sensitization, as indicated by studies in which prenatal exposure to maternal smoking was associated with an increased risk of tobacco use among adolescent offspring. We investigated wh...

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Bibliographic Details
Published in:American journal of epidemiology 2014-06, Vol.179 (12), p.1409-1417
Main Authors: RYDELL, Mina, MAGNUSSON, Cecilia, CNATTINGIUS, Sven, GRANATH, Fredrik, SVENSSON, Anna C, GALANTI, Maria Rosaria
Format: Article
Language:English
Subjects:
Adolescent
Adult Children
Biological and medical sciences
Child
Epidemiology
Female
General aspects
Humans
Male
Medical sciences
Medicin och hälsovetenskap
Miscellaneous
Mothers
Nicotine
Nicotine - adverse effects
Pregnancy
Prenatal Exposure Delayed Effects
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Factors
Smoking - adverse effects
Smoking - epidemiology
Surveys and Questionnaires
Sweden - epidemiology
Tobacco smoke
Tobacco Use - epidemiology
Tobacco, tobacco smoking
Toxicology
Young Adult
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Summary:Nicotine from maternal smoking during pregnancy can cross the placental barrier, possibly resulting in fetal brain sensitization, as indicated by studies in which prenatal exposure to maternal smoking was associated with an increased risk of tobacco use among adolescent offspring. We investigated whether this association persists beyond adolescence by studying cigarette smoking and the use of snus (Swedish oral moist snuff) among 983 young adults from a prospective cohort study conducted in Stockholm, Sweden, between 2006 and 2010. Self-reported questionnaire data were linked with data from national population-based registers from 1983 onward. Maternal smoking during pregnancy was consistently associated with snus use in offspring (e.g., for lifetime daily snus use, adjusted odds ratio = 2.04, 95% confidence interval: 1.32, 3.16; for use of >3 cans of snus per week vs. less, odds ratio = 3.85, 95% confidence interval: 1.57, 10.15). No association was apparent with offspring's smoking, age at onset of tobacco use, or changes in use between 2006 and 2010. These findings indicate that prenatal exposure to maternal smoking is associated with regular and heavy nicotine intake from smokeless tobacco rather than from smoking. This should be further explored in epidemiologic studies that simultaneously address the roles of genetics and social environments.
ISSN:0002-9262
1476-6256
1476-6256
DOI:10.1093/aje/kwu074