Bitter taste receptor (TAS2R) agonists inhibit IgE-dependent mast cell activation

Mast cell accumulation and redistribution have been described and correlated with lung function impairment. [...]it is currently accepted that mast cell infiltration of ASM in asthma contributes to airway hyperresponsiveness in asthma.4 In this context, it is possible that in addition to bronchodila...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2014-08, Vol.134 (2), p.475-478
Main Authors: Ekoff, Maria, PhD, Choi, Jeong-Hee, MD, PhD, James, Anna, PhD, Dahlén, Barbro, MD, PhD, Nilsson, Gunnar, PhD, Dahlén, Sven-Erik, MD, PhD
Format: Article
Language:English
Subjects:
Allergies
Allergy and Immunology
Asthma
Chloroquine - pharmacology
Dextromethorphan - pharmacology
Fetal Blood - cytology
Fetal Blood - immunology
Gene Expression Regulation - drug effects
Histamine
Histamine - biosynthesis
Humans
Immunoglobulin E - immunology
Mast Cells - cytology
Mast Cells - drug effects
Mast Cells - immunology
Noscapine - pharmacology
Prostaglandin D2 - antagonists & inhibitors
Prostaglandin D2 - secretion
Protein Isoforms - agonists
Protein Isoforms - genetics
Protein Isoforms - immunology
Quaternary Ammonium Compounds - pharmacology
Receptors, G-Protein-Coupled - agonists
Receptors, G-Protein-Coupled - genetics
Receptors, G-Protein-Coupled - immunology
Receptors, IgE - genetics
Receptors, IgE - immunology
Studies
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Summary:Mast cell accumulation and redistribution have been described and correlated with lung function impairment. [...]it is currently accepted that mast cell infiltration of ASM in asthma contributes to airway hyperresponsiveness in asthma.4 In this context, it is possible that in addition to bronchodilatory effects on ASM, TAS2Rs may affect signaling in mast cells.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2014.02.029