Infant wheeze, comorbidities and school age asthma

• Published in: Pediatric allergy and immunology 2014-06, Vol.25 (4), p.380-386
• Main Authors: Neuman, Åsa, Bergström, Anna, Gustafsson, Per, Thunqvist, Per, Andersson, Niklas, Nordvall, Lennart, Kull, Inger, Wickman, Magnus
• Format: Article
• Language: English
• Subjects: Age of Onset; Allergy and Milieu in Stockholm; an Epidemiologic study; Asthma; Asthma - diagnosis; Asthma - epidemiology; Babies; Barn/Children; Barn/Children, Allergy and Milieu in Stockholm, an Epidemiologic study; birth cohort; Child; Cohort Studies; Comorbidity; Disease Progression; Female; gastroesophageal reflux disease; Humans; Male; Medicin och hälsovetenskap; Pediatrics; prediction; Prognosis; Respiratory Sounds - diagnosis; Risk Factors; Sweden - epidemiology
• ISSN: 0905-6157; 1399-3038; 1399-3038
• DOI: 10.1111/pai.12223

Background Factors associated with early onset of wheeze have been described, but there is limited knowledge on which of these infant wheezers who will have developed asthma in school age. The aim was to identify clinical risk factors for asthma in the 8‐yr‐old children that wheezed during infancy in a population‐based setting. Methods Three thousand two hundred and fifty‐one children from a population‐based birth cohort followed prospectively from infancy until age 8 yr were included in the study. Data were analyzed using multivariate logistic regression analysis. Results Parents reported any wheeze episode before age 2 yr in 823 subjects (25%). Infant wheezers had an almost fourfold risk of asthma at age 8 [adjusted odds ratio (aOR) 3.68, 95% CI 2.74–4.96], equivalent to an asthma prevalence of 14% compared with 4% among non‐wheezers (p