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Infant wheeze, comorbidities and school age asthma
Background Factors associated with early onset of wheeze have been described, but there is limited knowledge on which of these infant wheezers who will have developed asthma in school age. The aim was to identify clinical risk factors for asthma in the 8‐yr‐old children that wheezed during infancy i...
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| Published in: | Pediatric allergy and immunology 2014-06, Vol.25 (4), p.380-386 |
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| container_end_page | 386 |
| container_issue | 4 |
| container_start_page | 380 |
| container_title | Pediatric allergy and immunology |
| container_volume | 25 |
| creator | Neuman, Åsa Bergström, Anna Gustafsson, Per Thunqvist, Per Andersson, Niklas Nordvall, Lennart Kull, Inger Wickman, Magnus |
| description | Background
Factors associated with early onset of wheeze have been described, but there is limited knowledge on which of these infant wheezers who will have developed asthma in school age. The aim was to identify clinical risk factors for asthma in the 8‐yr‐old children that wheezed during infancy in a population‐based setting.
Methods
Three thousand two hundred and fifty‐one children from a population‐based birth cohort followed prospectively from infancy until age 8 yr were included in the study. Data were analyzed using multivariate logistic regression analysis.
Results
Parents reported any wheeze episode before age 2 yr in 823 subjects (25%). Infant wheezers had an almost fourfold risk of asthma at age 8 [adjusted odds ratio (aOR) 3.68, 95% CI 2.74–4.96], equivalent to an asthma prevalence of 14% compared with 4% among non‐wheezers (p |
| doi_str_mv | 10.1111/pai.12223 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_522331</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1544012374</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6193-9c668befb907a158bba448c8616a49a81e6ba9b04eba1627272da267ec3b25ca3</originalsourceid><addsrcrecordid>eNqNkktvEzEUhS0EomlhwR9AI7EBqdP6NfZ4GRVIIpXCopSldT3jNG5nxqk9o7T8epzmgYQUCXthy_rO8bXvQegdwWckjfMluDNCKWUv0IgwpXKGWfkSjbDCRS5IIY_QcYx3GBPJBHmNjiiXFJcFGyE66-bQ9dlqYe1ve5pVvvXBuNr1zsYMujqL1cL7JoNbm0HsFy28Qa_m0ET7drueoJ9fv1xfTPPL75PZxfgyrwRRLFeVEKWxc6OwBFKUxgDnZVUKIoArKIkVBpTB3Boggso0a6BC2ooZWlTATlC-8Y0ruxyMXgbXQnjSHpzeHt2nndVFejkjiVcH-WXw9V_RTkioorJgUibt6UHtZ3cz1j7c6mHQlCpG1ld93ODJ92Gwsdeti5VtGuisH6ImBeeYUCb5f6BMSaw4Fgn98A9654fQpT9-pijmQq1L_bShquBjDHa-L5ZgvY6DTnHQz3FI7Put42BaW-_JXf8TcL4BVq6xT4ed9I_xbGe57YqLvX3cKyDcayGZLPSvq4me8uuryeTbjZ6yP3sjzEs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1539204697</pqid></control><display><type>article</type><title>Infant wheeze, comorbidities and school age asthma</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Neuman, Åsa ; Bergström, Anna ; Gustafsson, Per ; Thunqvist, Per ; Andersson, Niklas ; Nordvall, Lennart ; Kull, Inger ; Wickman, Magnus</creator><creatorcontrib>Neuman, Åsa ; Bergström, Anna ; Gustafsson, Per ; Thunqvist, Per ; Andersson, Niklas ; Nordvall, Lennart ; Kull, Inger ; Wickman, Magnus</creatorcontrib><description>Background
Factors associated with early onset of wheeze have been described, but there is limited knowledge on which of these infant wheezers who will have developed asthma in school age. The aim was to identify clinical risk factors for asthma in the 8‐yr‐old children that wheezed during infancy in a population‐based setting.
Methods
Three thousand two hundred and fifty‐one children from a population‐based birth cohort followed prospectively from infancy until age 8 yr were included in the study. Data were analyzed using multivariate logistic regression analysis.
Results
Parents reported any wheeze episode before age 2 yr in 823 subjects (25%). Infant wheezers had an almost fourfold risk of asthma at age 8 [adjusted odds ratio (aOR) 3.68, 95% CI 2.74–4.96], equivalent to an asthma prevalence of 14% compared with 4% among non‐wheezers (p < 0.001). After adjustments for sex, exposure to tobacco smoke and indoor dampness/mould, allergic heredity (aOR 1.53, 95% CI 1.02–2.30), increased frequency of wheeze (aOR 3.41, 95% CI 2.09–5.56 for children with ≥3 episodes compared with ≤2 episodes during the first 2 yr of life), infant eczema (aOR 2.31, 95% CI 1.52–3.49), and recurrent abdominal pain (aOR 2.33, 95% CI 1.30–4.16) remained risk factors for school age asthma in the infant wheezing group.
Conclusions
Among infant wheezers, allergic heredity, increased severity of wheeze, infant eczema, and recurrent abdominal pain were independent risk factors for asthma at age 8 yr. Among children with three or four of these risk factors, 38% had asthma at school age.</description><identifier>ISSN: 0905-6157</identifier><identifier>ISSN: 1399-3038</identifier><identifier>EISSN: 1399-3038</identifier><identifier>DOI: 10.1111/pai.12223</identifier><identifier>PMID: 24720853</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Age of Onset ; Allergy and Milieu in Stockholm ; an Epidemiologic study ; Asthma ; Asthma - diagnosis ; Asthma - epidemiology ; Babies ; Barn/Children ; Barn/Children, Allergy and Milieu in Stockholm, an Epidemiologic study ; birth cohort ; Child ; Cohort Studies ; Comorbidity ; Disease Progression ; Female ; gastroesophageal reflux disease ; Humans ; Male ; Medicin och hälsovetenskap ; Pediatrics ; prediction ; Prognosis ; Respiratory Sounds - diagnosis ; Risk Factors ; Sweden - epidemiology</subject><ispartof>Pediatric allergy and immunology, 2014-06, Vol.25 (4), p.380-386</ispartof><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2014 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6193-9c668befb907a158bba448c8616a49a81e6ba9b04eba1627272da267ec3b25ca3</citedby><cites>FETCH-LOGICAL-c6193-9c668befb907a158bba448c8616a49a81e6ba9b04eba1627272da267ec3b25ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24720853$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-229311$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:129275377$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Neuman, Åsa</creatorcontrib><creatorcontrib>Bergström, Anna</creatorcontrib><creatorcontrib>Gustafsson, Per</creatorcontrib><creatorcontrib>Thunqvist, Per</creatorcontrib><creatorcontrib>Andersson, Niklas</creatorcontrib><creatorcontrib>Nordvall, Lennart</creatorcontrib><creatorcontrib>Kull, Inger</creatorcontrib><creatorcontrib>Wickman, Magnus</creatorcontrib><title>Infant wheeze, comorbidities and school age asthma</title><title>Pediatric allergy and immunology</title><addtitle>Pediatr Allergy Immunol</addtitle><description>Background
Factors associated with early onset of wheeze have been described, but there is limited knowledge on which of these infant wheezers who will have developed asthma in school age. The aim was to identify clinical risk factors for asthma in the 8‐yr‐old children that wheezed during infancy in a population‐based setting.
Methods
Three thousand two hundred and fifty‐one children from a population‐based birth cohort followed prospectively from infancy until age 8 yr were included in the study. Data were analyzed using multivariate logistic regression analysis.
Results
Parents reported any wheeze episode before age 2 yr in 823 subjects (25%). Infant wheezers had an almost fourfold risk of asthma at age 8 [adjusted odds ratio (aOR) 3.68, 95% CI 2.74–4.96], equivalent to an asthma prevalence of 14% compared with 4% among non‐wheezers (p < 0.001). After adjustments for sex, exposure to tobacco smoke and indoor dampness/mould, allergic heredity (aOR 1.53, 95% CI 1.02–2.30), increased frequency of wheeze (aOR 3.41, 95% CI 2.09–5.56 for children with ≥3 episodes compared with ≤2 episodes during the first 2 yr of life), infant eczema (aOR 2.31, 95% CI 1.52–3.49), and recurrent abdominal pain (aOR 2.33, 95% CI 1.30–4.16) remained risk factors for school age asthma in the infant wheezing group.
Conclusions
Among infant wheezers, allergic heredity, increased severity of wheeze, infant eczema, and recurrent abdominal pain were independent risk factors for asthma at age 8 yr. Among children with three or four of these risk factors, 38% had asthma at school age.</description><subject>Age of Onset</subject><subject>Allergy and Milieu in Stockholm</subject><subject>an Epidemiologic study</subject><subject>Asthma</subject><subject>Asthma - diagnosis</subject><subject>Asthma - epidemiology</subject><subject>Babies</subject><subject>Barn/Children</subject><subject>Barn/Children, Allergy and Milieu in Stockholm, an Epidemiologic study</subject><subject>birth cohort</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Disease Progression</subject><subject>Female</subject><subject>gastroesophageal reflux disease</subject><subject>Humans</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>Pediatrics</subject><subject>prediction</subject><subject>Prognosis</subject><subject>Respiratory Sounds - diagnosis</subject><subject>Risk Factors</subject><subject>Sweden - epidemiology</subject><issn>0905-6157</issn><issn>1399-3038</issn><issn>1399-3038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNkktvEzEUhS0EomlhwR9AI7EBqdP6NfZ4GRVIIpXCopSldT3jNG5nxqk9o7T8epzmgYQUCXthy_rO8bXvQegdwWckjfMluDNCKWUv0IgwpXKGWfkSjbDCRS5IIY_QcYx3GBPJBHmNjiiXFJcFGyE66-bQ9dlqYe1ve5pVvvXBuNr1zsYMujqL1cL7JoNbm0HsFy28Qa_m0ET7drueoJ9fv1xfTPPL75PZxfgyrwRRLFeVEKWxc6OwBFKUxgDnZVUKIoArKIkVBpTB3Boggso0a6BC2ooZWlTATlC-8Y0ruxyMXgbXQnjSHpzeHt2nndVFejkjiVcH-WXw9V_RTkioorJgUibt6UHtZ3cz1j7c6mHQlCpG1ld93ODJ92Gwsdeti5VtGuisH6ImBeeYUCb5f6BMSaw4Fgn98A9654fQpT9-pijmQq1L_bShquBjDHa-L5ZgvY6DTnHQz3FI7Put42BaW-_JXf8TcL4BVq6xT4ed9I_xbGe57YqLvX3cKyDcayGZLPSvq4me8uuryeTbjZ6yP3sjzEs</recordid><startdate>201406</startdate><enddate>201406</enddate><creator>Neuman, Åsa</creator><creator>Bergström, Anna</creator><creator>Gustafsson, Per</creator><creator>Thunqvist, Per</creator><creator>Andersson, Niklas</creator><creator>Nordvall, Lennart</creator><creator>Kull, Inger</creator><creator>Wickman, Magnus</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope></search><sort><creationdate>201406</creationdate><title>Infant wheeze, comorbidities and school age asthma</title><author>Neuman, Åsa ; Bergström, Anna ; Gustafsson, Per ; Thunqvist, Per ; Andersson, Niklas ; Nordvall, Lennart ; Kull, Inger ; Wickman, Magnus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6193-9c668befb907a158bba448c8616a49a81e6ba9b04eba1627272da267ec3b25ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Age of Onset</topic><topic>Allergy and Milieu in Stockholm</topic><topic>an Epidemiologic study</topic><topic>Asthma</topic><topic>Asthma - diagnosis</topic><topic>Asthma - epidemiology</topic><topic>Babies</topic><topic>Barn/Children</topic><topic>Barn/Children, Allergy and Milieu in Stockholm, an Epidemiologic study</topic><topic>birth cohort</topic><topic>Child</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Disease Progression</topic><topic>Female</topic><topic>gastroesophageal reflux disease</topic><topic>Humans</topic><topic>Male</topic><topic>Medicin och hälsovetenskap</topic><topic>Pediatrics</topic><topic>prediction</topic><topic>Prognosis</topic><topic>Respiratory Sounds - diagnosis</topic><topic>Risk Factors</topic><topic>Sweden - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neuman, Åsa</creatorcontrib><creatorcontrib>Bergström, Anna</creatorcontrib><creatorcontrib>Gustafsson, Per</creatorcontrib><creatorcontrib>Thunqvist, Per</creatorcontrib><creatorcontrib>Andersson, Niklas</creatorcontrib><creatorcontrib>Nordvall, Lennart</creatorcontrib><creatorcontrib>Kull, Inger</creatorcontrib><creatorcontrib>Wickman, Magnus</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><jtitle>Pediatric allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neuman, Åsa</au><au>Bergström, Anna</au><au>Gustafsson, Per</au><au>Thunqvist, Per</au><au>Andersson, Niklas</au><au>Nordvall, Lennart</au><au>Kull, Inger</au><au>Wickman, Magnus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infant wheeze, comorbidities and school age asthma</atitle><jtitle>Pediatric allergy and immunology</jtitle><addtitle>Pediatr Allergy Immunol</addtitle><date>2014-06</date><risdate>2014</risdate><volume>25</volume><issue>4</issue><spage>380</spage><epage>386</epage><pages>380-386</pages><issn>0905-6157</issn><issn>1399-3038</issn><eissn>1399-3038</eissn><abstract>Background
Factors associated with early onset of wheeze have been described, but there is limited knowledge on which of these infant wheezers who will have developed asthma in school age. The aim was to identify clinical risk factors for asthma in the 8‐yr‐old children that wheezed during infancy in a population‐based setting.
Methods
Three thousand two hundred and fifty‐one children from a population‐based birth cohort followed prospectively from infancy until age 8 yr were included in the study. Data were analyzed using multivariate logistic regression analysis.
Results
Parents reported any wheeze episode before age 2 yr in 823 subjects (25%). Infant wheezers had an almost fourfold risk of asthma at age 8 [adjusted odds ratio (aOR) 3.68, 95% CI 2.74–4.96], equivalent to an asthma prevalence of 14% compared with 4% among non‐wheezers (p < 0.001). After adjustments for sex, exposure to tobacco smoke and indoor dampness/mould, allergic heredity (aOR 1.53, 95% CI 1.02–2.30), increased frequency of wheeze (aOR 3.41, 95% CI 2.09–5.56 for children with ≥3 episodes compared with ≤2 episodes during the first 2 yr of life), infant eczema (aOR 2.31, 95% CI 1.52–3.49), and recurrent abdominal pain (aOR 2.33, 95% CI 1.30–4.16) remained risk factors for school age asthma in the infant wheezing group.
Conclusions
Among infant wheezers, allergic heredity, increased severity of wheeze, infant eczema, and recurrent abdominal pain were independent risk factors for asthma at age 8 yr. Among children with three or four of these risk factors, 38% had asthma at school age.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24720853</pmid><doi>10.1111/pai.12223</doi><tpages>7</tpages></addata></record> |
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| ispartof | Pediatric allergy and immunology, 2014-06, Vol.25 (4), p.380-386 |
| issn | 0905-6157 1399-3038 1399-3038 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Age of Onset Allergy and Milieu in Stockholm an Epidemiologic study Asthma Asthma - diagnosis Asthma - epidemiology Babies Barn/Children Barn/Children, Allergy and Milieu in Stockholm, an Epidemiologic study birth cohort Child Cohort Studies Comorbidity Disease Progression Female gastroesophageal reflux disease Humans Male Medicin och hälsovetenskap Pediatrics prediction Prognosis Respiratory Sounds - diagnosis Risk Factors Sweden - epidemiology |
| title | Infant wheeze, comorbidities and school age asthma |
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