NGF-induced mechanical sensitization of the masseter muscle is mediated through peripheral NMDA receptors

• Published in: Neuroscience 2014-06, Vol.269, p.232-244
• Main Authors: Wong, H, Kang, I, Dong, X.-D, Christidis, N, Ernberg, M, Svensson, P, Cairns, B.E
• Format: Article
• Language: English
• Subjects: 2-Amino-5-phosphonovalerate - pharmacology; Animals; Biological and medical sciences; Cell Size; Excitatory Amino Acid Antagonists - pharmacology; Female; Fundamental and applied biological sciences. Psychology; Humans; Hyperalgesia - drug therapy; Hyperalgesia - pathology; Hyperalgesia - physiopathology; masseter muscle; Masseter Muscle - drug effects; Masseter Muscle - physiopathology; Nerve Growth Factor; Neurology; Neurons - drug effects; Neurons - pathology; Neurons - physiology; nociceptors; Nociceptors - drug effects; Nociceptors - pathology; Nociceptors - physiology; Pain Threshold - drug effects; Pain Threshold - physiology; Physical Stimulation; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate - metabolism; sensitization; Sex Characteristics; Species Specificity; temporomandibular disorders; Touch; trigeminal; Trigeminal Ganglion - drug effects; Trigeminal Ganglion - pathology; Trigeminal Ganglion - physiopathology; Vertebrates: nervous system and sense organs
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.03.054

Highlights • NGF induced long lasting mechanical sensitization in masseter muscle in rats. • NGF-induced mechanical sensitization was greater in female than male rats. • APV reversed NGF-induced mechanical sensitization in male but not female rats. • NGF increased NMDA expression in masseter nociceptors in both sexes. • NMDA expression in masseter nociceptors was similar between humans and rats.