Parental age and the risk of autism spectrum disorders: findings from a Swedish population-based cohort

The objectives of this study were to examine the independent and dependent associations of maternal and paternal age and risk of offspring autism spectrum disorders (ASD), with and without intellectual disability (ID). The sample consisted of 417 303 Swedish children born 1984-2003. ASD case status...

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Bibliographic Details
Published in:International journal of epidemiology 2014-02, Vol.43 (1), p.107-115
Main Authors: IDRING, Selma, MAGNUSSON, Cecilia, LUNDBERG, Michael, EK, Mats, RAI, Dheeraj, SVENSSON, Anna C, DALMAN, Christina, KARLSSON, Håkan, LEE, Brian K
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Child
Child clinical studies
Child Development Disorders, Pervasive - epidemiology
Child Development Disorders, Pervasive - etiology
Child, Preschool
Developmental disorders
Epidemiology
Female
General aspects
Humans
Infant
Infantile autism
Intellectual Disability - epidemiology
Longitudinal Studies
Male
Maternal Age
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Miscellaneous
Parents
Paternal Age
Population Surveillance
Prospective Studies
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk
Risk Factors
Socioeconomic Factors
Sweden - epidemiology
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Summary:The objectives of this study were to examine the independent and dependent associations of maternal and paternal age and risk of offspring autism spectrum disorders (ASD), with and without intellectual disability (ID). The sample consisted of 417 303 Swedish children born 1984-2003. ASD case status (N = 4746) was ascertained using national and regional registers. Smoothing splines in generalized additive models were used to estimate associations of parental age with ASD. Whereas advancing parental age increased the risk of child ASD, maternal age effects were non-linear and paternal age effects were linear. Compared with mothers at the median age 29 years, those
ISSN:0300-5771
1464-3685
1464-3685
DOI:10.1093/ije/dyt262