Minimally-invasive treatment of early stage breast cancer: A feasibility study using radiofrequency ablation under local anesthesia

Abstract The objective of this study was to assess efficacy and safety of percutaneous ultrasound (US) guided preferential radiofrequency ablation (PRFA) in early breast carcinoma under local anesthesia and to evaluate a new assessment protocol. Eighteen breast cancer patients were enrolled in order...

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Bibliographic Details
Published in:Breast (Edinburgh) 2014-04, Vol.23 (2), p.152-158
Main Authors: Schässburger, Kai-Uwe, Löfgren, Lars, Lagerstedt, Ulla, Leifland, Karin, Thorneman, Karin, Sandstedt, Bengt, Auer, Gert, Wiksell, Hans
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anesthesia, Local
Breast cancer
Breast Neoplasms - surgery
Catheter Ablation - methods
Feasibility Studies
Female
Hematology, Oncology and Palliative Medicine
Humans
Medicin och hälsovetenskap
Middle Aged
Minimally invasive
Minimally Invasive Surgical Procedures - methods
Pain Measurement
Radiofrequency ablation
Small breast carcinoma
Treatment Outcome
Ultrasonography, Interventional - methods
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Summary:Abstract The objective of this study was to assess efficacy and safety of percutaneous ultrasound (US) guided preferential radiofrequency ablation (PRFA) in early breast carcinoma under local anesthesia and to evaluate a new assessment protocol. Eighteen breast cancer patients were enrolled in order to receive PRFA treatment three weeks prior to resection. Pain assessment was performed using the visual analoge scale. Analysis of treatment success was performed using magnetic resonance imaging (MRI) as well as histological assays for hematoxylin & eosin (H&E) and cytokeratine 8 (CK8). In a subset of patients contrast enhanced ultrasound (CEUS) was performed before and after treatment. MRI showed no residual tumor growth in 100% (18/18) of cases. Complete tumor devitalization was indicated in 83% (15/18) of patients as judged by H&E staining and in 89% (16/18) as judged by immunostaining for CK8. In 100% (18/18) at least one histologic method showed devitalization in the entire tumor. Treatment was well tolerated. Pain experienced during the procedure was mild. US-guided PRFA of small breast carcinoma is feasible under local anesthesia. MRI and CK8 have proven valuable additions to the RF breast tumor ablation protocol. CEUS shows potential as a modality for radiological follow-up.
ISSN:0960-9776
1532-3080
1532-3080
DOI:10.1016/j.breast.2013.12.007