Evaluation of Systemic Levels of Neutrophilic Enzymes in Patients With Hypertension and Chronic Periodontitis

• Published in: Journal of periodontology (1970) 2014-07, Vol.85 (7), p.908-916
• Main Authors: Türkoğlu, Oya, Barış, Nezihi, Tervahartiala, Taina, Şenarslan, Ömer, Sorsa, Timo, Atilla, Gül
• Format: Article
• Language: English
• Subjects: Adult; Case-Control Studies; Chronic Periodontitis - blood; Chronic Periodontitis - enzymology; Dental Plaque Index; Dentistry; Female; Humans; hypertension; Hypertension - blood; Hypertension - enzymology; Inflammation; Leukocyte Elastase - blood; Male; Matrix Metalloproteinase 8 - blood; Matrix Metalloproteinase 9 - blood; matrix metalloproteinases; Medicin och hälsovetenskap; Middle Aged; neutrophils; Neutrophils - enzymology; Periodontal Attachment Loss - blood; Periodontal Attachment Loss - enzymology; periodontal diseases; Periodontal Index; Periodontal Pocket - blood; Periodontal Pocket - enzymology; Peroxidase - blood; Tissue Inhibitor of Metalloproteinase-1 - blood; tissue inhibitor of metalloproteinases
• ISSN: 0022-3492; 1943-3670; 1943-3670
• DOI: 10.1902/jop.2013.130346

Background: Inflammation stimulates neutrophils to release their enzymes into the extracellular matrix. The aim of the present study is to investigate the serum levels of matrix metalloproteinase (MMP)‐8, MMP‐9, tissue inhibitor of MMP (TIMP)‐1, myeloperoxidase (MPO), and neutrophil elastase (NE) in patients with hypertension and chronic periodontitis (CP). Methods: A total of 95 patients were included in the study. Patients were categorized into three groups: healthy control (n = 29), hypertensive control (n = 32), and hypertensive CP (n = 34). Periodontal parameters were recorded, and serum samples were collected from each participant. Serum MMP‐8, MMP‐9, TIMP‐1, MPO, and NE levels in circulation were assessed by enzyme‐linked immunosorbent assay. Results: The hypertensive CP group had significantly higher serum MMP‐8, MMP‐9, and NE levels than the healthy control group (P 0.05). Significantly higher serum MPO levels were detected in patients with hypertension and CP than healthy controls and hypertensive controls (P 0.05). There was no significant difference in MMP‐8/TIMP‐1 ratio among the study groups (P >0.05). MMP‐9/TIMP‐1 ratio was significantly higher in patients with hypertension and CP than healthy controls (P