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Haemophilus influenzae Resides in Tonsils and Uses Immunoglobulin D Binding as an Evasion Strategy
Haemophilus influenzae (Hi) causes respiratory tract infections and is also considered to be a commensal, particularly in preschool children. Tonsils from patients (n = 617) undergoing tonsillectomy due to chronic infection or hypertrophy were examined. We found that 51% of tonsils were positive for...
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| Published in: | The Journal of infectious diseases 2014-05, Vol.209 (9), p.1418-1428 |
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| Main Authors: | , , , , , |
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| cites | cdi_FETCH-LOGICAL-c455t-b68ac4a6f168a97ddde2f4ca8004834c23468c3b8ed496e24c293d9a128f5a8e3 |
| container_end_page | 1428 |
| container_issue | 9 |
| container_start_page | 1418 |
| container_title | The Journal of infectious diseases |
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| creator | Singh, Kalpana Nordström, Therese Mörgelin, Matthias Brant, Marta Cardell, Lars-Olaf Riesbeck, Kristian |
| description | Haemophilus influenzae (Hi) causes respiratory tract infections and is also considered to be a commensal, particularly in preschool children. Tonsils from patients (n = 617) undergoing tonsillectomy due to chronic infection or hypertrophy were examined. We found that 51% of tonsils were positive for Hi, and in 95% of cases analyzed in detail (n = 39) Hi resided intracellularly in the core tonsillar tissue. Patients harbored several intracellular unique strains and the majority were nontypeable Hi (NTHi). Interestingly, the isolated NTHi bound soluble immunoglobulin (Ig) D at the constant heavy chain domain 1 as revealed by recombinant IgD/IgG chimeras. NTHi also interacted with B lymphocytes via the IgD B-cell receptor, resulting in intemalization of bacteria, T-cel-independent activation via Toll-like receptor 9, and differentiation into non-NTHi-specific IgM-producing cells. Taken together, IgD-binding NTHi leads to an unspecific immune response and may support the bacteria to circumvent the host defense. |
| doi_str_mv | 10.1093/infdis/jit593 |
| format | article |
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Tonsils from patients (n = 617) undergoing tonsillectomy due to chronic infection or hypertrophy were examined. We found that 51% of tonsils were positive for Hi, and in 95% of cases analyzed in detail (n = 39) Hi resided intracellularly in the core tonsillar tissue. Patients harbored several intracellular unique strains and the majority were nontypeable Hi (NTHi). Interestingly, the isolated NTHi bound soluble immunoglobulin (Ig) D at the constant heavy chain domain 1 as revealed by recombinant IgD/IgG chimeras. NTHi also interacted with B lymphocytes via the IgD B-cell receptor, resulting in intemalization of bacteria, T-cel-independent activation via Toll-like receptor 9, and differentiation into non-NTHi-specific IgM-producing cells. Taken together, IgD-binding NTHi leads to an unspecific immune response and may support the bacteria to circumvent the host defense.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/jit593</identifier><identifier>PMID: 24218509</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; B lymphocytes ; B-Lymphocytes - immunology ; Bacteria ; Bacteriology ; Biological and medical sciences ; Child ; Endocytosis ; Female ; Fundamental and applied biological sciences. Psychology ; Haemophilus Infections - epidemiology ; Haemophilus Infections - immunology ; Haemophilus Infections - microbiology ; Haemophilus influenzae ; Haemophilus influenzae - immunology ; Haemophilus influenzae - isolation & purification ; Haemophilus influenzae - metabolism ; Humans ; Hypertrophy ; Immune Evasion ; Immunoglobulin D - immunology ; Immunoglobulin D - metabolism ; Immunoglobulins ; Infections ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Miscellaneous ; Palatine Tonsil - microbiology ; Palatine tonsils ; Pathogens ; Solubility ; Sweden - epidemiology ; Toll-Like Receptor 9 - immunology ; Young Adult</subject><ispartof>The Journal of infectious diseases, 2014-05, Vol.209 (9), p.1418-1428</ispartof><rights>Copyright © 2014 Oxford University Press on behalf of the Infectious Diseases Society of America</rights><rights>The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. 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Tonsils from patients (n = 617) undergoing tonsillectomy due to chronic infection or hypertrophy were examined. We found that 51% of tonsils were positive for Hi, and in 95% of cases analyzed in detail (n = 39) Hi resided intracellularly in the core tonsillar tissue. Patients harbored several intracellular unique strains and the majority were nontypeable Hi (NTHi). Interestingly, the isolated NTHi bound soluble immunoglobulin (Ig) D at the constant heavy chain domain 1 as revealed by recombinant IgD/IgG chimeras. NTHi also interacted with B lymphocytes via the IgD B-cell receptor, resulting in intemalization of bacteria, T-cel-independent activation via Toll-like receptor 9, and differentiation into non-NTHi-specific IgM-producing cells. Taken together, IgD-binding NTHi leads to an unspecific immune response and may support the bacteria to circumvent the host defense.</description><subject>Adolescent</subject><subject>B lymphocytes</subject><subject>B-Lymphocytes - immunology</subject><subject>Bacteria</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Endocytosis</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Haemophilus Infections - epidemiology</subject><subject>Haemophilus Infections - immunology</subject><subject>Haemophilus Infections - microbiology</subject><subject>Haemophilus influenzae</subject><subject>Haemophilus influenzae - immunology</subject><subject>Haemophilus influenzae - isolation & purification</subject><subject>Haemophilus influenzae - metabolism</subject><subject>Humans</subject><subject>Hypertrophy</subject><subject>Immune Evasion</subject><subject>Immunoglobulin D - immunology</subject><subject>Immunoglobulin D - metabolism</subject><subject>Immunoglobulins</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Palatine Tonsil - microbiology</subject><subject>Palatine tonsils</subject><subject>Pathogens</subject><subject>Solubility</subject><subject>Sweden - epidemiology</subject><subject>Toll-Like Receptor 9 - immunology</subject><subject>Young Adult</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkc1v1DAQxS0EokvhyBHkCxKXUH_HOUJpaaVKSNCeLcd2Fi-OHeIYVP76epVle-Tk0fPPb8bzAHiN0QeMOnrm42B9Ptv5hXf0CdhgTttGCEyfgg1ChDRYdt0JeJHzDiHEqGifgxPCCJYcdRvQX2k3pumHDyXD6hWKi3-1g99c9tbtJXibYvYhQx0tvMtVux7HEtM2pL6Eev8ZfvLR-riFeg_Bi986-xTh92XWi9vevwTPBh2ye3U4T8Hd5cXt-VVz8_XL9fnHm8YwzpemF1IbpsWAa9G11lpHBma0rFNLygyhTEhDe-ks64QjVemo7TQmcuBaOnoKmtU3_3FT6dU0-1HP9ypprw7Sz1o5xQkXsq38-5Wf5vSruLyo0WfjQtDRpZIV5pgLxhEVj9ZmTjnPbjiaY6T2Mag1BrXGUPm3B-vSj84e6X97r8C7A6Cz0WGYdTT1-ZGTrH62RY8zpjL9t-ebFd3lJc1HmNEWybpA-gCx96sG</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Singh, Kalpana</creator><creator>Nordström, Therese</creator><creator>Mörgelin, Matthias</creator><creator>Brant, Marta</creator><creator>Cardell, Lars-Olaf</creator><creator>Riesbeck, Kristian</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20140501</creationdate><title>Haemophilus influenzae Resides in Tonsils and Uses Immunoglobulin D Binding as an Evasion Strategy</title><author>Singh, Kalpana ; Nordström, Therese ; Mörgelin, Matthias ; Brant, Marta ; Cardell, Lars-Olaf ; Riesbeck, Kristian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-b68ac4a6f168a97ddde2f4ca8004834c23468c3b8ed496e24c293d9a128f5a8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>B lymphocytes</topic><topic>B-Lymphocytes - immunology</topic><topic>Bacteria</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Endocytosis</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Haemophilus Infections - epidemiology</topic><topic>Haemophilus Infections - immunology</topic><topic>Haemophilus Infections - microbiology</topic><topic>Haemophilus influenzae</topic><topic>Haemophilus influenzae - immunology</topic><topic>Haemophilus influenzae - isolation & purification</topic><topic>Haemophilus influenzae - metabolism</topic><topic>Humans</topic><topic>Hypertrophy</topic><topic>Immune Evasion</topic><topic>Immunoglobulin D - immunology</topic><topic>Immunoglobulin D - metabolism</topic><topic>Immunoglobulins</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Palatine Tonsil - microbiology</topic><topic>Palatine tonsils</topic><topic>Pathogens</topic><topic>Solubility</topic><topic>Sweden - epidemiology</topic><topic>Toll-Like Receptor 9 - immunology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singh, Kalpana</creatorcontrib><creatorcontrib>Nordström, Therese</creatorcontrib><creatorcontrib>Mörgelin, Matthias</creatorcontrib><creatorcontrib>Brant, Marta</creatorcontrib><creatorcontrib>Cardell, Lars-Olaf</creatorcontrib><creatorcontrib>Riesbeck, Kristian</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singh, Kalpana</au><au>Nordström, Therese</au><au>Mörgelin, Matthias</au><au>Brant, Marta</au><au>Cardell, Lars-Olaf</au><au>Riesbeck, Kristian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Haemophilus influenzae Resides in Tonsils and Uses Immunoglobulin D Binding as an Evasion Strategy</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>2014-05-01</date><risdate>2014</risdate><volume>209</volume><issue>9</issue><spage>1418</spage><epage>1428</epage><pages>1418-1428</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Haemophilus influenzae (Hi) causes respiratory tract infections and is also considered to be a commensal, particularly in preschool children. Tonsils from patients (n = 617) undergoing tonsillectomy due to chronic infection or hypertrophy were examined. We found that 51% of tonsils were positive for Hi, and in 95% of cases analyzed in detail (n = 39) Hi resided intracellularly in the core tonsillar tissue. Patients harbored several intracellular unique strains and the majority were nontypeable Hi (NTHi). Interestingly, the isolated NTHi bound soluble immunoglobulin (Ig) D at the constant heavy chain domain 1 as revealed by recombinant IgD/IgG chimeras. NTHi also interacted with B lymphocytes via the IgD B-cell receptor, resulting in intemalization of bacteria, T-cel-independent activation via Toll-like receptor 9, and differentiation into non-NTHi-specific IgM-producing cells. Taken together, IgD-binding NTHi leads to an unspecific immune response and may support the bacteria to circumvent the host defense.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>24218509</pmid><doi>10.1093/infdis/jit593</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2014-05, Vol.209 (9), p.1418-1428 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | Oxford Journals Online; JSTOR |
| subjects | Adolescent B lymphocytes B-Lymphocytes - immunology Bacteria Bacteriology Biological and medical sciences Child Endocytosis Female Fundamental and applied biological sciences. Psychology Haemophilus Infections - epidemiology Haemophilus Infections - immunology Haemophilus Infections - microbiology Haemophilus influenzae Haemophilus influenzae - immunology Haemophilus influenzae - isolation & purification Haemophilus influenzae - metabolism Humans Hypertrophy Immune Evasion Immunoglobulin D - immunology Immunoglobulin D - metabolism Immunoglobulins Infections Infectious diseases Male Medical sciences Microbiology Miscellaneous Palatine Tonsil - microbiology Palatine tonsils Pathogens Solubility Sweden - epidemiology Toll-Like Receptor 9 - immunology Young Adult |
| title | Haemophilus influenzae Resides in Tonsils and Uses Immunoglobulin D Binding as an Evasion Strategy |
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