Angiogenesis and Vascular Functions in Modulation of Obesity, Adipose Metabolism, and Insulin Sensitivity

White and brown adipose tissues are hypervascularized and the adipose vasculature displays phenotypic and functional plasticity to coordinate with metabolic demands of adipocytes. Blood vessels not only supply nutrients and oxygen to nourish adipocytes, they also serve as a cellular reservoir to pro...

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Bibliographic Details
Published in:Cell metabolism 2013-10, Vol.18 (4), p.478-489
Main Author: Cao, Yihai
Format: Article
Language:English
Subjects:
Adipocytes - cytology
Adipocytes - metabolism
Angiogenesis Modulating Agents - metabolism
Cell Differentiation
Cytokines - metabolism
Endothelial Cells - cytology
Endothelial Cells - metabolism
Humans
Insulin Resistance
Neovascularization, Physiologic
Obesity - metabolism
Obesity - physiopathology
SAMHÄLLSVETENSKAP
SOCIAL SCIENCES
Vascular Endothelial Growth Factor A - metabolism
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Summary:White and brown adipose tissues are hypervascularized and the adipose vasculature displays phenotypic and functional plasticity to coordinate with metabolic demands of adipocytes. Blood vessels not only supply nutrients and oxygen to nourish adipocytes, they also serve as a cellular reservoir to provide adipose precursor and stem cells that control adipose tissue mass and function. Multiple signaling molecules modulate the complex interplay between the vascular system and the adipocytes. Understanding fundamental mechanisms by which angiogenesis and vasculatures modulate adipocyte functions may provide new therapeutic options for treatment of obesity and metabolic disorders by targeting the adipose vasculature.
ISSN:1550-4131
1932-7420
1932-7420
DOI:10.1016/j.cmet.2013.08.008