Lung diffusing capacity for nitric oxide at lowered and raised ambient pressures

Highlights • The lung diffusing capacity for nitric oxide (DLNO ) was determined in healthy humans at ambient pressures ranging 0.5–4.0 atmospheres absolute (ATA). • The diffusivity for NO in the background gas was 8 times lower at the highest pressure than at the lowest. • Data fitted a model with...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2013-12, Vol.189 (3), p.552-557
Main Authors: Linnarsson, Dag, Hemmingsson, Tryggve E, Frostell, Claes, Van Muylem, Alain, Kerckx, Yannick, Gustafsson, Lars E
Format: Article
Language:English
Subjects:
Adult
Atmospheric Pressure
Capillary Permeability
Diffusivity
Female
Gas density
Humans
Hyperbaria
Hypobaria
Male
Medical Education
Medicin och hälsovetenskap
Nitric Oxide - metabolism
Pulmonary Alveoli - physiology
Pulmonary Diffusing Capacity - physiology
Pulmonary/Respiratory
Young Adult
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Summary:Highlights • The lung diffusing capacity for nitric oxide (DLNO ) was determined in healthy humans at ambient pressures ranging 0.5–4.0 atmospheres absolute (ATA). • The diffusivity for NO in the background gas was 8 times lower at the highest pressure than at the lowest. • Data fitted a model with a decreasing conductance through the gas phase in the peripheral lung with higher pressure. • DLNO was estimated to be 5% lower than DmNO at 1.0 ATA and 17% lower than DmNO at 4.0 ATA.
ISSN:1569-9048
1878-1519
1878-1519
DOI:10.1016/j.resp.2013.08.008