S1 is Associated with Chronic Low Back Pain: A Functional and Structural MRI Study

A fundamental characteristic of neural circuits is the capacity for plasticity in response to experience. Neural plasticity is associated with the development of chronic pain disorders. In this study, we investigated 1) brain resting state functional connectivity (FC) differences between patients wi...

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Bibliographic Details
Published in:Molecular pain 2013-08, Vol.9 (1), p.43-43
Main Authors: Kong, Jian, Spaeth, B, Wey, Hsiao-Ying, Cheetham, Alexandra, Cook, Amanda H, Jensen, Karin, Tan, Ying, Liu, Hesheng, Wang, Danhong, Loggia, Marco L, Napadow, Vitaly, Smoller, Jordan W, Wasan, Ajay D, Gollub, Randy L
Format: Article
Language:English
Subjects:
Adult
Back pain
Brain
Brain - pathology
Brain - physiopathology
Chronic Pain - pathology
Chronic Pain - physiopathology
Development and progression
Diagnosis
Experiments
Humans
Low back pain
Low Back Pain - pathology
Low Back Pain - physiopathology
Magnetic Resonance Imaging
Male
Medical imaging
Medical research
Medicin och hälsovetenskap
Medicine, Experimental
Middle Aged
Neural circuitry
Neurophysiology
Neurosciences
Studies
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Summary:A fundamental characteristic of neural circuits is the capacity for plasticity in response to experience. Neural plasticity is associated with the development of chronic pain disorders. In this study, we investigated 1) brain resting state functional connectivity (FC) differences between patients with chronic low back pain (cLBP) and matched healthy controls (HC); 2) FC differences within the cLBP patients as they experienced different levels of endogenous low back pain evoked by exercise maneuvers, and 3) morphometric differences between cLBP patients and matched HC We found the dynamic character of FC in the primary somatosensory cortex (S1) in cLBP patients, i.e., S1 FC decreased when the patients experienced low intensity LBP as compared with matched healthy controls, and FC at S1 increased when cLBP patients experienced high intensity LBP as compared with the low intensity condition. In addition, we also found increased cortical thickness in the bilateral S1 somatotopically associated with the lower back in cLBP patients as compared to healthy controls. Our results provide evidence of structural plasticity co-localized with areas exhibiting FC changes in S1 in cLBP patients.
ISSN:1744-8069
1744-8069
DOI:10.1186/1744-8069-9-43