Short telomere length is associated with NOTCH1/SF3B1/TP53 aberrations and poor outcome in newly diagnosed chronic lymphocytic leukemia patients

Most previous studies on telomere length (TL) in chronic lymphocytic leukemia (CLL) are based on referral cohorts including a high proportion of aggressive cases. Here, the impact of TL was analyzed in a population‐based cohort of newly diagnosed CLL (n = 265) and in relation to other prognostic mar...

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Published in:American journal of hematology 2013-08, Vol.88 (8), p.647-651
Main Authors: Mansouri, Larry, Grabowski, Pawel, Degerman, Sofie, Svenson, Ulrika, Gunnarsson, Rebeqa, Cahill, Nicola, Smedby, Karin Ekström, Geisler, Christian, Juliusson, Gunnar, Roos, Göran, Rosenquist, Richard
Format: Article
Language:English
Subjects:
Aged
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Cancer och onkologi
Clinical Medicine
Disease-Free Survival
Female
Follow-Up Studies
Hematologi
Hematology
Humans
Klinisk medicin
Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - mortality
Leukemia, Lymphocytic, Chronic, B-Cell - therapy
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Middle Aged
Mutation
Phosphoproteins - genetics
Phosphoproteins - metabolism
Predictive Value of Tests
Receptor, Notch1 - genetics
Receptor, Notch1 - metabolism
Retrospective Studies
Ribonucleoprotein, U2 Small Nuclear - genetics
Ribonucleoprotein, U2 Small Nuclear - metabolism
RNA Splicing Factors
Survival Rate
Telomere - genetics
Telomere - metabolism
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
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Summary:Most previous studies on telomere length (TL) in chronic lymphocytic leukemia (CLL) are based on referral cohorts including a high proportion of aggressive cases. Here, the impact of TL was analyzed in a population‐based cohort of newly diagnosed CLL (n = 265) and in relation to other prognostic markers. Short telomeres were particularly associated with high‐risk genetic markers, such as NOTCH1, SF3B1, or TP53 aberrations, and predicted a short time to treatment (TTT) and overall survival (OS) (both P 
ISSN:0361-8609
1096-8652
1096-8652
DOI:10.1002/ajh.23466