The Impact of Succimer Chelation on Blood Cadmium in Children with Background Exposures: A Randomized Trial

Succimer lowers blood lead concentrations in children, and the structure of succimer chelates of lead and cadmium are similar. Using blood samples from a randomized trial of succimer for lead poisoning, however, we found that succimer did not lower blood cadmium in children with background exposure.

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Bibliographic Details
Published in:The Journal of pediatrics 2013-08, Vol.163 (2), p.598-600
Main Authors: Cao, Yang, PhD, Chen, Aimin, MD, PhD, Bottai, Matteo, ScD, Caldwell, Kathleen L., PhD, Rogan, Walter J., MD
Format: Article
Language:English
Subjects:
blood
cadmium
Cadmium - blood
chelates
Chelating Agents - therapeutic use
chelation
Chelation Therapy
Child
children
Environmental Exposure - adverse effects
Humans
lead
lead poisoning
Lead Poisoning - blood
Lead Poisoning - drug therapy
Limit of detection
LOD
Pediatrics
Succimer - therapeutic use
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Description
Summary:Succimer lowers blood lead concentrations in children, and the structure of succimer chelates of lead and cadmium are similar. Using blood samples from a randomized trial of succimer for lead poisoning, however, we found that succimer did not lower blood cadmium in children with background exposure.
ISSN:0022-3476
1097-6833
1097-6833
DOI:10.1016/j.jpeds.2013.03.009